Results 21 to 30 of about 732 (170)
Química Nova, 2007 Quassinoids, the bitter principles of the Simaroubaceae family, are a group of structurally complex and highly oxygenated degraded triterpenes. They are divided into five groups according to their basic skeleton, C-18, C-19, C-20, C-22 and C-25.
Maria Mozarina Beserra Almeida +5 more
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A novel P38α MAPK activator Bruceine A exhibits potent anti-pancreatic cancer activity
Computational and Structural Biotechnology Journal, 2021 Pancreatic cancer remains one of the cancers with the poorest prognosis bearing an overall 5-year survival rate of about 5%. Efficient new chemotherapic drugs are still highly desired.
Cai Lu +10 more
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Data in Brief, 2019 Ailanthone is a quassinoid from Ailanthus altissima (Mill.) Swingle with allelopathic properties that deserves interest for its potential use as a natural herbicide. Data about seed germination and root and hypocotyl length of two model species (Lepidium
Sonia Demasi +5 more
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The toxic effects and possible mechanisms of Brusatol on mouse oocytes. [PDF]
PLoS ONE, 2017 Brusatol is a natural quassinoid that shows a potential therapeutic use in cancer models by the inhibition of Nuclear factor erythroid 2-related factor 2 (Nrf2) and is capable of inducing a variety of biological effects. The effects of Brusatol on oocyte
Rujun Ma +6 more
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Acta Pharmaceutica Sinica B, 2021 Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1α (HIF-1α) is a major regulator involved in cellular response to changes of oxygen ...
Rui Huang +12 more
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Quassinoids from the Roots of Eurycoma longifolia and Their Anti-Proliferation Activities
Molecules, 2021 A phytochemical investigation on the roots of medicinal plant Eurycoma longifolia resulted in the isolation of 10 new highly oxygenated C20 quassinoids longifolactones G‒P (1–10), along with four known ones (11–14). Their chemical structures and absolute
Wei-Qun Yang +9 more
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Production of eurycomanone from cell suspension culture of Eurycoma longifolia
Pharmaceutical Biology, 2017 Context: Eurycomanone is found in the Eurycoma longifolia Jack (Simaroubaceae) tree, exhibits significant antimalarial activity, improves spermatogenesis, suppresses expression of lung cancer cell tumour markers and regulates signalling pathways involved
Nguyen Huu Nhan, Nguyen Hoang Loc
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Acta Crystallographica Section E, 2010 The title compound, C26H34O11, known as bruceine A, is a natural quassinoid extracted from the dried fruits of Brucea javanica. Its structure consists of five fused rings including an oxygen-containing heterocyclic ring and a lactone ring.
Xue-Huan Feng +4 more
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The botanical eurycomanone is a potent growth regulator of the diamondback moth
Ecotoxicology and Environmental Safety, 2021 Eurycomanone is a quassinoid compound that is derived from Eurycoma longifolia, and it is often used as an indicator to evaluate the active ingredients of Eurycoma longifolia.
Xuehua Shao +5 more
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A brief overview of antitumoral actions of bruceine D
Exploration of Targeted Anti-tumor Therapy, 2020 Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy.
Zi Wayne Sin +3 more
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