Results 1 to 10 of about 1,106 (106)

Combining network pharmacology and experimental validation to study the action and mechanism of brusatol against lung adenocarcinoma [PDF]

Scientific Reports
Brusatol is a natural product found in the plant Brucea javanica that is used to treat diseases such as amoebiasis and malaria. It also has significant anti-tumor effects.
Xin Jin, Shixiong Yang, Dianzhu Pan, Bo Jin, Ye Zhang, Chunjiao Yang   +5 more
doaj   +2 more sources

Pharmacokinetics and nephrotoxicity of cisplatin modulated by combination therapy with brusatol [PDF]

Frontiers in Pharmacology
Ethnopharmacological RelevanceQuassinoid brusatol, isolated from the traditional Chinese medicine Brucea javanica (L.) Merr., significantly increases the intracellular concentration of cisplatin and reduces tumor size by inhibiting the Nrf2 pathway ...
Nan Guo, Yahui Zhang, Guiyan Yuan, Xiaoran Zhang, Wen Zhang, Qing Wen   +5 more
doaj   +2 more sources

The Nrf2 inhibitor brusatol synergistically enhances the cytotoxic effect of lapatinib in HER2-positive cancers

Heliyon, 2022
The dual tyrosine kinase (EGFR/HER2) inhibitor lapatinib is currently used to clinically treat HER2-positive breast cancer. However, a majority of patients do not respond to lapatinib therapy within 6 months. Therefore, potentiating the anti-tumor effect
Chunpo Ge
exaly   +3 more sources

Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis [PDF]

Chinese Medicine
Background Psoriasis-associated dyslipidemia presents as a critical comorbidity characterized by a self-perpetuating cycle of metabolic dysfunction and chronic inflammation.
Yuankuan Jiang, Shumeng Zhang, Hewen Guan, Kejia lv, Jinchao Yu, Siyi Li, Renchuan Jia, Xiujie Zhang, Shurong Ma, Jialin Qu, Jingrong Lin   +10 more
doaj   +2 more sources

Iloprost, a Prostacyclin Analogue, Alleviates Oxidative Stress and Improves Development of Parthenogenetic Porcine Embryos via Nrf2/Keap1 Signaling [PDF]

Antioxidants
Background: Prostacyclin (PGI2), an abundantly produced bioactive lipid by oviductal epithelial cells, supports preimplantation embryo development by buffering oxidative stress.
Eun Young Choi, Kyungjun Uh, Seol-Bin Lee, Pil-Soo Jeong, Hyo-Gu Kang, Se-Been Jeon, Ji Hyeon Yun, Hee-Chang Son, Kyung-Seob Lim, You Jeong An, Sun-Uk Kim, Seong-Keun Cho, Bong-Seok Song   +12 more
doaj   +2 more sources

Characterization of brusatol self-microemulsifying drug delivery system and its therapeutic effect against dextran sodium sulfate-induced ulcerative colitis in mice

Drug Delivery, 2017
Brusatol (BR) is one of the main bioactive components derived from Brucea javanica, a medicinal herb historically used in the treatment of dysenteric disorders (also known as ulcerative colitis(UC)).
Lihua Tan, Jianhui Xie, Zhengquan Lai
exaly   +2 more sources

Asperosaponin VI Alleviates Cisplatin‐Induced Liver Injury Through the Nrf2/HO‐1 Signaling Pathway [PDF]

Immunity, Inflammation and Disease
Background Cisplatin (Cis) chemotherapy‐induced hepatotoxicity frequently leads to treatment interruption or dose reduction, ultimately compromising therapeutic outcomes.
Han‐hua Li, Xiao‐ming Zhou, Chuan‐wei Sun, Zhi‐feng Huang, Zu‐an Liu, Hongming Lou, Huining Bian, Shao‐yi Zheng, Wen Lai, XueQing Yao   +9 more
doaj   +2 more sources

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma

Journal of Advanced Research, 2020
Introduction: Epithelial-mesenchymal transition (EMT) is a process of transdifferentiation where epithelial cells attain mesenchymal phenotype to gain invasive properties and thus, can contribute to metastasis of tumor cells.
Amudha Deivasigamani, Young Yun Jung, Basappa Basappa   +2 more
exaly   +3 more sources

Brusatol inhibits metastasis of triple-negative breast cancer through metabolic reprogramming [PDF]

Frontiers in Oncology
BackgroundTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) characterized by a high risk of metastasis and poor prognosis. Current chemotherapy-based treatments are often limited by systemic toxicity and drug resistance.
Xuan Yu, Xuan Yu, Xueling Diao, Xueling Diao, Xiaokai Fan, Xiaokai Fan, Chuantao Wu, Siyuan Wang, Maoxuan Liu, Maoxuan Liu, Edwin Cheung, Liang Chen, Liang Chen   +12 more
doaj   +2 more sources

Portulaca oleracea-derived indoline amide ameliorates obesity and NAFLD in rats through Nrf2-dependent antioxidant and anti-inflammatory mechanisms [PDF]

Scientific Reports
In this study, we evaluated the potential of indoline amide extract phenolic extract Portulaca oleracea (POIA-PE) in preventing obesity and non-alcoholic fatty liver disease (NAFLD) in rats and depicted the possible mechanism of action. Adult male Wistar
Mona Eid Alshamari, Laila Naif Al-Harbi, Ghedeir M. Alshammari, Maha H. Alhussain, Ali Saleh, Mohammed Abdo Yahya   +5 more
doaj   +2 more sources