Correction: Pharmacokinetics and nephrotoxicity of cisplatin modulated by combination therapy with brusatol [PDF]
Frontiers in PharmacologyNan Guo +5 more
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The toxic effects and possible mechanisms of Brusatol on mouse oocytes. [PDF]
PLoS ONE, 2017 Brusatol is a natural quassinoid that shows a potential therapeutic use in cancer models by the inhibition of Nuclear factor erythroid 2-related factor 2 (Nrf2) and is capable of inducing a variety of biological effects. The effects of Brusatol on oocyte
Rujun Ma +6 more
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Brusatol, an NRF2 inhibitor for future cancer therapeutic [PDF]
Cell & Bioscience, 2019 Background Natural products from herbal medicines have long been investigated for their potentials as cancer therapeutics. Besides the development of several herbal medicine-derived anti-cancer agents, such as paclitaxel, vincristine and podophyllotoxin,
Sabrina J. Cai +3 more
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Acta Crystallographica Section E, 2012 The title compound, C26H32O11, is composed of an α,β-unsaturated cyclohexanone ring (A), two cyclohexane rings (B and C), a six-membered lactone ring (D) and tetrahydrofuran ring (E).
Shu-Zhi Hu +4 more
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Brusatol Inhibits Proliferation and Invasion of Glioblastoma by Down-Regulating the Expression of ECM1 [PDF]
Frontiers in Pharmacology, 2021 Brusatol (Bru), a Chinese herbal extract, has a variety of anti-tumor effects. However, little is known regarding its role and underlying mechanism in glioblastoma cells.
Zhang’an Dai +10 more
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Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatol
Results in Chemistry, 2023 Three fluorinated quassinoid analogues—4α-fluorobruceosin, 1α-fluorobrusatol, and 1-fluorodehydrobrusatol—were synthesized from brusatol, bruceosin, and dehydrobrusatol, respectively, by treatment with Selectfluor.
Yukio Hitotsuyanagi +5 more
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Effects of different concentrations of brusatol on silicosis fibrosis in mice
环境与职业医学BackgroundSilicosis is a diffuse fibrosis of the lungs caused by long-term inhalation of free silicon dioxide (SiO2). It has a complex pathogenesis and lacks effective treatment.
Huimin KANG +4 more
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KEAP1-NRF2 Pathway as a Novel Therapeutic Target for EGFR-Mutant Non-small Cell Lung Cancer [PDF]
Tuberculosis and Respiratory DiseasesBackground Kelch-like ECH-associated protein 1 (KEAP1)–nuclear factor erythroid-2-related factor 2 (NRF2) pathway is a major regulator protecting cells from oxidative and metabolic stress.
Jae-Sun Choi +8 more
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Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke [PDF]
Chinese MedicineObjective Electroacupuncture has been shown to play a neuroprotective role following ischemic stroke, but the underlying mechanism remains poorly understood. Ferroptosis has been shown to play a key role in the injury process.
Xi-chen Yang +8 more
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Aloesin activates Nrf2 signaling to attenuate obesity-associated oxidative stress and hepatic steatosis in high-fat diet-fed rats [PDF]
Scientific ReportsNon-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder characterized by hepatic steatosis, oxidative stress, and chronic inflammation.
Sarah M. Alamri +5 more
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