Results 31 to 40 of about 1,175 (153)

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

BMC Cancer, 2018
Background We previously showed that knockdown of nuclear factor E2-related factor 2 (Nrf2) resulted in suppression of hepatitis C virus (HCV) infection.
Yuko Murakami, Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Keisuke Ojiro, Po-sung Chu, Nobuhito Taniki, Yoshimasa Saito, Toshiaki Teratani, Yuzo Koda, Takahiro Suzuki, Kyoko Saito, Masayoshi Fukasawa, Masanori Ikeda, Nobuyuki Kato, Takanori Kanai, Hidetsugu Saito   +16 more
doaj   +1 more source

Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats

Redox Report, 2023
Objectives To observe the protective effects of dexmedetomidine (Dex) postconditioning on myocardial ischemia/reperfusion injury (IRI) and to explore its potential molecular mechanisms.Methods One-hundred forty-seven male Sprague-Dawley rats were ...
Bin Hu, Tian Tian, Xin-Tao Li, Pei-Pei Hao, Wei-Chao Liu, Ying-Gui Chen, Tian-Yu Jiang, Pei-Shan Chen, Yi Cheng, Fu-Shan Xue   +9 more
doaj   +1 more source

Targeting the NRF2/HO-1 Antioxidant Pathway in FLT3-ITD-Positive AML Enhances Therapy Efficacy

Antioxidants, 2022
Acute myeloid leukemia (AML) is a molecularly heterogenous hematological malignancy, with one of the most common mutations being internal tandem duplication (ITD) of the juxtamembrane domain of the fms-like tyrosine kinase receptor-3 (FLT3).
Sankaranarayan Kannan, Mary E. Irwin, Shelley M. Herbrich, Tiewei Cheng, LaNisha L. Patterson, Marisa J. L. Aitken, Kapil Bhalla, M. James You, Marina Konopleva, Patrick A. Zweidler-McKay, Joya Chandra   +10 more
doaj   +1 more source

Larvicidal Activity of Brusatol Isolated from Brucea javanica (L) Merr on Culex quinquefasciatus

Iranian Journal of Public Health, 2019
Background: Vector control is still emphasized on the using of chemical insecticide which can cause death of non-target organisms, pollution and vector resistance.
Dwi SUTININGSIH, Nurjazuli NURJAZULI, Djoko NUGROHO, Tri Baskoro Tunggul SATOTO   +3 more
doaj   +1 more source

Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia reperfusion in mice [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose To investigate the effects of grape seed proanthocyanidin B2 (GSPB2) preconditioning on oxidative stress and apoptosis of renal tubular epithelial cells in mice after renal ischemia-reperfusion (RIR).
Zhi-shun Wang, Hai-hong Zhou, Qi Han, Yong-lian Guo, Zhong-yuan Li   +4 more
doaj   +1 more source

Brusatol Suppresses Bladder Cancer by downregulating the expression of Nrf2

, 2022
Abstract A substance called brunsatol, which is derived from the dried ripe fruit of Brucea javanica, has been shown to be active against a variety of human cancers, but not against bladder cancer (BCa). In the present study, we attempted to investigate the effect of brusatol in BCa and verify whether Nrf2 was involved in the mechanism.
Xi Yu, Shenglan Li, Huaxing Wang, Chenglin Ye, Lei Wang, Xiuheng Liu   +5 more
openaire   +1 more source

Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas [PDF]

Oxidative Medicine and Cellular Longevity, 2021
Cabergoline (CAB) is the first choice for treatment of prolactinoma and the most common subtype of pituitary adenoma. However, drug resistance and lack of effectiveness in other pituitary tumor types remain clinical challenges to this treatment. Brusatol (BT) is known to inhibit cell growth and promote apoptosis in a variety of cancer cells.
Zerui Wu, Yunqiu Xu, Jiadong Xu, Jianglong Lu, Lin Cai, Qun Li, Chengde Wang, Zhipeng Su   +7 more
openaire   +2 more sources

Brusatol Derivative–34 Attenuates Allergic Airway Inflammation Via Inhibition of the Spleen Tyrosine Kinase Pathway

Frontiers in Pharmacology, 2021
Brusatol derivative-34 (Bru-34), a derivative of brusatol, has been shown significantly anti-inflammatory activity in mice in our previously work. However, to our knowledge, there were very limited studies on how Bru-34 affected airway inflammation. Thus,
Yasi Ding, Weibin Tang, Fei Pei, Lixia Fu, Pei Ma, Jinye Bai, Mingbao Lin, Yunbao Liu, Qi Hou   +8 more
doaj   +1 more source

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism [PDF]

Proceedings of the National Academy of Sciences, 2011
The major obstacle in cancer treatment is the resistance of cancer cells to therapies. Nrf2 is a transcription factor that regulates a cellular defense response and is ubiquitously expressed at low basal levels in normal tissues due to Keap1-dependent ubiquitination and proteasomal degradation.
Dongmei, Ren, Nicole F, Villeneuve, Tao, Jiang, Tongde, Wu, Alexandria, Lau, Henry A, Toppin, Donna D, Zhang   +6 more
openaire   +2 more sources

Synergistic antitumor effect of brusatol combined with cisplatin on colorectal cancer cells

International Journal of Molecular Medicine, 2018
Colorectal cancer (CRC) is a common and life‑threatening type of malignant cancer, which is associated with a high mortality rate. Cisplatin (CDDP) is a commonly used chemotherapy drug with significant side effects. Brusatol (BR) is one of the principal chemical compounds isolated from the Chinese herb Bruceae Fructus, which has been reported to ...
Chen, Hai-Ming, Lai, Zheng-Quan, Liao, Hui-Jun, Xie, Jian-Hui, Xian, Yan-Fang, Chen, Yun-Long, Ip, Siu-Po, Lin, Zhi-Xiu, Su, Zi-Ren   +8 more
openaire   +3 more sources