Results 1 to 10 of about 300 (90)

Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction [PDF]

Acta Pharmaceutica Sinica B, 2021
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1α (HIF-1α) is a major regulator involved in cellular response to changes of oxygen ...
Sanhong Liu, Xin Luan, Wei-Dong Zhang
exaly   +4 more sources

Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathway [PDF]

Cancer Medicine, 2019
Patients with osteosarcoma exhibiting resistance to chemotherapy or presenting with metastasis usually have a poor prognosis. Osteosarcoma stem cells (OSCs) are a potential cause of tumor metastasis, relapse, and chemotherapy resistance. Therefore, it is
Shangyu Wang, Hongzhi Hu, Binlong Zhong, Deyao Shi, Xiangcheng Qing, Cheng Cheng, Xiangyu Deng, Zhicai Zhang, Zengwu Shao   +8 more
doaj   +3 more sources

Bruceine D Identified as a Drug Candidate against Breast Cancer by a Novel Drug Selection Pipeline and Cell Viability Assay [PDF]

Pharmaceuticals, 2022
The multi-target effects of natural products allow us to fight complex diseases like cancer on multiple fronts. Unlike docking techniques, network-based approaches such as genome-scale metabolic modelling can capture multi-target effects.
Claudia Cipriani, Maria Pires Pacheco, Ali Kishk, Maryem Wachich, Daniel Abankwa, Elisabeth Schaffner-Reckinger, Thomas Sauter   +6 more
doaj   +2 more sources

A brief overview of antitumoral actions of bruceine D [PDF]

Exploration of Targeted Anti-tumor Therapy, 2020
Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy.
Zi Wayne Sin, Vipul Bhardwaj, Amit Kumar Pandey, Manoj Garg   +3 more
doaj   +2 more sources

Network-Based Approach to Identify the Antiproliferative Mechanisms of Bruceine D in Breast Cancer From the Cancer Genome Atlas [PDF]

Frontiers in Oncology, 2020
Bruceine D (BD) is a natural compound extracted from a Chinese herb Brucea javanica that has been used for anti-inflammatory and anti-cancer treatment. However, little is reported about BD's effects in breast cancer tumorigenesis. In this paper, we aimed
Saisai Tian, Rui Jing, Weidong Zhang, Weidong Zhang   +3 more
doaj   +2 more sources

Bruceine D inhibits Cell Proliferation Through Downregulating LINC01667/MicroRNA-138-5p/Cyclin E1 Axis in Gastric Cancer [PDF]

Frontiers in Pharmacology, 2020
Objective: Gastric cancer is one of the most common malignant tumors. Bruceine D (BD) is one of the extracts of Brucea javanica. In recent years, it has been reported that BD has anti-tumor activity in some human cancers through different mechanisms ...
Lin Li, Lin Li, Lin Li, Lin Li, Lin Li, Zhen Dong, Zhen Dong, Zhen Dong, Zhen Dong, Zhen Dong, Pengfei Shi, Pengfei Shi, Pengfei Shi, Pengfei Shi, Li Tan, Li Tan, Li Tan, Li Tan, Jie Xu, Jie Xu, Jie Xu, Jie Xu, Pan Huang, Pan Huang, Pan Huang, Pan Huang, Zhongze Wang, Zhongze Wang, Zhongze Wang, Zhongze Wang, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui, Liqun Yang, Liqun Yang, Liqun Yang, Liqun Yang   +38 more
doaj   +2 more sources

Inhibition of STAT3-mediated glycolysis by bruceine D suppresses non-small-cell lung cancer progression in vitro and in vivo [PDF]

Cancer Biology & Therapy
Background Non-small-cell lung cancer (NSCLC) is one of the deadliest malignancies in the world. Signal transducer and activator of transcription 3 (STAT3) plays an important role in the progression of NSCLC. Bruceine D is a bioactive quassinoid compound
Yu Zhu, Xuan Xu, Xiaofan Hong, Jiayi Zhang, Yi Zhou, Aofeng Sun, Yihan Ye, Yini Xu, Huanhai Xu, Haiyang Zhao, Chengguang Zhao, Xing Jin, Lehe Yang, Jianxiao Zheng   +13 more
doaj   +2 more sources

Bruceine D and Narclasine inhibit the proliferation of breast cancer cells and the prediction of potential drug targets. [PDF]

PLoS ONE
BackgroundBreast cancer is one of the most common female malignancies. This study explored the underlying mechanism through which the two plant compounds (Brucaine D and Narclasine) inhibited the proliferation of breast cancer cells.ObjectiveThe purpose ...
Xinhao Chen, Hua Li
doaj   +2 more sources

Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis [PDF]

Redox Biology
Skin pan-fibrosis diseases—such as hypertrophic scar (HS), keloid scar (KS), and systemic sclerosis (SSc)—pose significant threats to patients' health and quality of life.
Jianzhang Wang, Yajuan Song, Xiaoying Tan, Tong Wang, Yi Shi, Xingbo Xu, Juan Du, Zhou Yu, Baoqiang Song   +8 more
doaj   +2 more sources

Bruceine D inhibits hepatocellular carcinoma by regulating the STAT3 signaling pathway through HSP70 [PDF]

European Journal of Medical Research
Background Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with limited effective therapies and poor prognosis.
Pu Chen, Qing Xu, Shuling Wu, Fanyun Zhu, Yi Zhou, Qingqing Lin, Min Zhao, Ju Yang, Haiyang Zhao, Bin Zhou, Chengguang Zhao   +10 more
doaj   +2 more sources