Results 21 to 30 of about 350 (114)

Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis. [PDF]

Int J Nanomedicine, 2018
Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]).To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of ...
Dou YX, Zhou JT, Wang TT, Huang YF, Chen VP, Xie YL, Lin ZX, Gao JS, Su ZR, Zeng HF.   +9 more
europepmc   +6 more sources

Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
Abstract Background Gemcitabine (GEM) is a chemotherapeutic drug used to treat pancreatic ductal adenocarcinoma carcinoma (PDAC), but chemoresistance is often encountered clinically. Nrf2, an oxidative stress responsive transcription factor, is an important contributor to chemoresistance and is closely associated with poor prognosis of PDAC ...
Juan Zhang, Hong-Xi Xu, William Chi Shing Cho, Wah Cheuk, Yang Li, Qiong-Hui Huang, Wen Yang, Yan-Fang Xian, Zhi-Xiu Lin   +8 more
openaire   +3 more sources

Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo. [PDF]

Cell Death Dis, 2020
AbstractWorldwide, lung cancer remains a leading cause of cancer mortality. Bruceine D (BD) has been shown to induce pancreatic cancer cell death via several different mechanisms. In this study, we demonstrated that BD inhibited lung cancer cell proliferation. Apoptosis and autophagy were the most important mechanisms involved in BD-induced lung cancer
Fan J, Ren D, Wang J, Liu X, Zhang H, Wu M, Yang G.   +6 more
europepmc   +4 more sources

Effects of KCNQ1OT1 Gene Knockout Combined with Bruceine D on Proliferation, Migration, and Invasion of Breast Cancer MDA-MB-231 Cells

Zhongliu Fangzhi Yanjiu, 2023
Objective To explore the effect of KCNQ1OT1 gene knockout combined with bruceine D on the proliferation, migration, and invasion of breast cancer MDA-MB-231 cells.
LONG Feng, ZHAO Yu, HUANG Yong, LIU Xiaoyan, ZHOU Xuan, LI Xue, YE Hailin   +6 more
doaj   +1 more source

The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells. [PDF]

Exp Ther Med, 2020
Brucein D (BD) is a naturally occurring major active quassinoid extracted from the Chinese medicinal herb Brucea javanica, which has been previously demonstrated to exhibit anticancer activities. The present study aimed to investigate the anticancer effects of BD on MDA-MB-231 cells, a human triple-negative breast cancer (TNBC) cell line.
Luo C, Wang Y, Wei C, Chen Y, Ji Z.
europepmc   +4 more sources

Apoptosis induced by bruceine D in human non‑small‑cell lung cancer cells involves mitochondrial ROS‑mediated death signaling. [PDF]

Int J Mol Med, 2019
Bruceine D is one of the active components of Brucea javanica (L.) Merr., which is widely used to treat cancer in China. The aim of the present study was to evaluate the potential effect of bruceine D against non‑small‑cell lung cancer (NSCLC) cells and delineate its underlying mechanisms.
Xie JH, Lai ZQ, Zheng XH, Xian YF, Li Q, Ip SP, Xie YL, Chen JN, Su ZR, Lin ZX, Yang XB.   +10 more
europepmc   +4 more sources

Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence

Journal of Cellular and Molecular Medicine, Volume 27, Issue 19, Page 2841-2863, October 2023., 2023
Abstract The most common type of cancer in the world is lung cancer. Traditional treatments have an important role in cancer therapy. In the present review, the most recent findings on the effects of medicinal plants and their constituents or natural products (NP) in treating lung cancer are discussed. Empirical studies until the end of March 2022 were
Arghavan Memarzia, Saeideh Saadat, Fereshteh Asgharzadeh, Sepide Behrouz, Gert Folkerts, Mohammad Hossein Boskabady   +5 more
wiley   +1 more source

Identification of Bruceine A as a novel HSP90AB1 inhibitor for suppressing hepatocellular carcinoma growth [PDF]

Journal of Advanced Research
Lemei Zhu
exaly   +2 more sources

In Silico Evaluation of Natural Compounds for an Acidic Extracellular Environment in Human Breast Cancer

Cells, 2021
The survival rates for breast cancer (BC) have improved in recent years, but resistance, metastasis, and recurrence still remain major therapeutic challenges for BC.
YoungJoon Park, Jaekwang Jeong, Shin Seong, Wonnam Kim   +3 more
doaj   +1 more source

Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway‐Mediated Apoptosis and Modulating Tryptophan Metabolism

Journal of Diabetes Research, Volume 2023, Issue 1, 2023., 2023
Diabetic nephropathy (DN) is a metabolic disease wherein chronic hyperglycemia triggers various renal cell dysfunctions, eventually leading to progressive kidney failure. Rosa laevigata Michx. is a traditional Chinese herbal medicine. Many studies have confirmed its antioxidative, anti‐inflammatory, and renoprotective effects.
Tianyu Zhang, Wenjuan Sun, Lixin Wang, Hui Zhang, Yuansong Wang, Baochao Pan, Hanzhou Li, Ziang Ma, Kai Xu, Huantian Cui, Shuquan Lv, Rosa Fernandes   +11 more
wiley   +1 more source