Results 41 to 50 of about 350 (114)

Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway. [PDF]

Am J Cancer Res, 2016
Chronic myeloid leukemia (CML), an acquired malignant myeloproliferative disorder of hematopoietic stem cells, is one of the three most common forms of leukemia. In this study, we investigated the effects of bruceine D, which have been isolated from Brucea javanica (L.) Merr. on human chronic myeloid leukemia K562 cells.
Zhang JY, Lin MT, Tung HY, Tang SL, Yi T, Zhang YZ, Tang YN, Zhao ZZ, Chen HB.   +8 more
europepmc   +2 more sources

Cytotoxicity and Apoptosis Studies of Brucein D against T24 Bladder Cancer Cells

Asian Pacific Journal of Cancer Prevention
Brucein D (BrD), a quassinoid isolated from Brucea javanica fruit, reportedly demonstrates anti-cancer activity. This study's objective is to evaluate the cytotoxicity of Brucein D and its ability to induce apoptosis in T24 bladder cancer cells.We investigated the cytotoxic activity of BrD against the T24 cell through the induction of apoptosis in ...
Nandana, Pandu Ishaq, Rasyid, Haerani, Prihantono, Prihantono, Yustisia, Ika, Hakim, Lukman, Bukhari, Agussalim, Prasedya, Eka Sunarwidhi   +6 more
openaire   +2 more sources

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 8, August 2025.
Targeting ECM dysregulation: therapeutic strategies for disease intervention. Dysregulated ECM composition and biomechanics contribute to disease pathogenesis in cancer and fibrotic disorders. Physical modulation: Nanomedicine‐based strategies tune ECM physical properties (e.g., density, stiffness) to enhance drug penetration and therapeutic efficacy ...
Tian Zhao, Ye Huang, Jingfei Zhu, Yujie Qin, Hao Wu, Jiaxuan Yu, Qianwen Zhai, Shun Li, Xiang Qin, Dengfeng Wang, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Brucein D modulates MAPK signaling cascade to exert multi-faceted anti-neoplastic actions against breast cancer cells

Biochimie, 2021
Breast cancer is a prominent type of malignancy among women with a high rate of mortality. A number of previous studies have demonstrated the anticancer potential of brucein D (BD), a quassinoid extracted from Brucea javanica, against the cancers of the pancreas, bone, and liver.
Chakrabhavi Dhananjaya Mohan, Yin Yin Liew, Young Yun Jung, Shobith Rangappa, Habbanakuppe D. Preetham, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Zhi-Xiu Lin, Kanchugarakoppal S. Rangappa, Kwang Seok Ahn   +10 more
openaire   +3 more sources

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

Advanced Science, Volume 12, Issue 20, May 29, 2025.
AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang   +15 more
wiley   +1 more source

Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis of various cancers. While ROS primarily originate from normal cellular processes, external stimuli can also contribute to their production. Cancer cells typically exhibit elevated ROS levels due to disrupted redox homeostasis,
Iqra Attique, Zahra Haider, Maha Khan, Samina Hassan, Mohamed Mohamed Soliman, Wisam Nabeel Ibrahim, Sumaira Anjum   +6 more
wiley   +1 more source

Phytohormones and emerging plant growth regulators in tailoring plant immunity against viral infections

Physiologia Plantarum, Volume 177, Issue 2, March/April 2025.
Abstract Viral infections are major contributors to crop yield loss and represent a significant threat to sustainable agriculture. Plants respond to virus attacks by activating sophisticated signalling cascades that initiate multiple defence mechanisms.
Kritika Shukla, Nikita, Altaf Ahmad, Md Salik Noorani, Ravi Gupta   +4 more
wiley   +1 more source

Mechanisms Underlying the Therapeutic Effects of Brucea javanica in Cervical Cancer Treatment Based on Network Pharmacology and Molecular Docking

International Journal of Genomics, Volume 2025, Issue 1, 2025.
Aims: The aim of this study was to systematically analyze the role of Brucea javanica in the treatment of cervical cancer (CC) and its underlying mechanisms by means of network pharmacology and molecular docking. Background:Brucea javanica is a traditional Chinese herbal medicine used for the treatment of malaria and cancers, but its mechanism of ...
Wen Jin, Bin Li, Lu Zhang, Chenyang Sun, Yiping Liu, Minghua Ren   +5 more
wiley   +1 more source

The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside

MedComm, Volume 5, Issue 8, August 2024.
Metabolic disorders seriously endanger the health of human beings. However, there are no approved drugs specific for metabolic disorders. Recently, sever natural products have been demonstrated to alleviate metabolic disorders, and also used as chemical probes to identify their functional targets, which are involved in insulin resistance, glycolipid ...
Xiaofei Shen, Hongling Yang, Yang Yang, Xianjun Zhu, Qingxiang Sun   +4 more
wiley   +1 more source

Expression and Clinical Significance of DAP3 in Breast Cancer and Effect of Bruceine D on Expression of DAP3:Analysis Based on Data-mining from Bioinformatics

康复学报, 2019
Objective:To clarify the expression and significance of DAP3 in breast cancer, and further explore the effect of Bruceine D on the expression of DAP3 gene in breast cancer cells.Methods:The datasets about the expression of DAP3 gene in breast cancer were
Wenlong WANG, Qingzhi KONG, Hongda LU, Qingdong XIANG, Dianlei LIU   +4 more
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