Results 31 to 40 of about 350 (114)

[Retracted] Effect of Shenqi Fuzheng Injection on Leukopenia and T‐cell Subsets in Patients with Non‐small Cell Lung Cancer Undergoing Radiotherapy

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Purpose. The aim of this study is to evaluate the effect of Shenqi fuzheng injection on leukopenia and T‐cell subsets in patients with non‐small cell lung cancer (NSCLC) undergoing radiotherapy. Methods. A total of 124 patients with advanced NSCLC treated in the oncology department of our hospital from January 2017 to January 2019 were included and ...
Chengde Wu, Ying Liang, Fangyong Fu, Tian jiao Wang   +3 more
wiley   +1 more source

Anthelmintic Agents from African Medicinal Plants: Review and Prospects

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Soil‐transmitted helminthiasis affects more than 1.5 billion people globally and largely remains a sanitary problem in Africa. These infections place a huge economic burden on poor countries and affect livestock production, causing substantial economic losses and poor animal health. The emergence of anthelmintic resistance, especially in livestock, and
Jonathan Jato, Emmanuel Orman, Yaw Duah Boakye, Emelia Oppong Bekoe, Samuel Oppong Bekoe, Samuel Asare-Nkansah, Verena Spiegler, Andreas Hensel, Eva Liebau, Christian Agyare, Harish Chandra   +10 more
wiley   +1 more source

Ficus pandurata Hance Inhibits Ulcerative Colitis and Colitis‐Associated Secondary Liver Damage of Mice by Enhancing Antioxidation Activity

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Inflammatory bowel disease (IBD), a global disease threatening human health, is commonly accompanied by secondary liver damage (SLD) mediated by the gut‐liver axis. Oxidative stress acts a critical role in the onset of IBD, during which excessive oxidation would destroy the tight junctions between intestinal cells, promote proinflammatory factors to ...
Weibo Dai, Xinyi Zhan, Weijie Peng, Xin Liu, Weiwen Peng, Quanxi Mei, Xianjing Hu, Kai Wang   +7 more
wiley   +1 more source

Brusatol‐Enriched Brucea javanica Oil Ameliorated Dextran Sulfate Sodium‐Induced Colitis in Mice: Involvement of NF‐κB and RhoA/ROCK Signaling Pathways

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Brucea javanica oil (BJO) is beneficial for the treatment of ulcerative colitis (UC), and that quassinoids in particular brusatol are bioactive components. However, it is still uncertain whether or not other components in BJO, such as oleic acid and fatty acids, have an anti‐UC effect. The present study is aimed at comparing the anti‐UC effects between
Xinghan Zheng, Liting Mai, Tongtong Wang, Ying Xu, Zireng Su, Jiannan Chen, Huifang Zeng, Youliang Xie, Rui Liu   +8 more
wiley   +1 more source

Molecular docking studies of Brucein D as a potential inhibitor of the Bcl-2 anti-apoptotic protein

Bali Medical Journal, 2023
Link of Video Abstract: https://youtu.be/JOzTSty10v4Background: Brucein D (BrD), a quassinoid isolated from Brucea javanica fruit, reportedly demonstrates anti-tumor activity. Bcl-2 is an anti-apoptotic protein that inhibits apoptosis and leads to cancer progression.
Pandu Ishaq Nandana, Haerani Rasyid, null Prihantono, Ika Yustisia, Lukman Hakim   +4 more
openaire   +1 more source

Anti-babesial Quassinoids from the Fruits of

Natural Product Communications, 2008
The medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae), grown in China, was examined for anti-babesial properties. The anti-babesial activity of the fruit was found to be attributed to its quassinoid constituents.
Ahmed Elkhateeb, Masahiro Yamasaki, Yoshimitsu Maede, Ken Katakura, Kensuke Nabeta, Hideyuki Matsuura   +5 more
doaj   +1 more source

A study on the mechanism of bruceine D in the treatment of non-small cell lung cancer H1299 cells

World Journal of Traditional Chinese Medicine, 2020
Background: Non-small cell lung cancer (NSCLC) is considered one of the leading causes of cancer-related death. Despite the availability of drugs for the treatment of NSCLC, the need for the development of novel agents with high efficiency and fewer adverse effects remains unmet. The natural compound bruceine D (BD) is widely recognized for its notable
Jian-Ye Zhang, Bolat Makabel, Xiao-Yun Shen, Chao-Yue Su, Yan-Yan Yan, Ling-Ling Zhang, Qiao-Ru Guo, Hu-Biao Chene, Shuhela Zhumabieke, Yelxat Danabek, Jia-Jun Li, Yun Liu   +11 more
openaire   +1 more source

Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells

International Journal of Molecular Medicine, 2012
The fruit of Brucea javanica L. is a common herb used in Chinese medicine for the treatment of a variety of cancers. Our research group has previously identified bruceine D (BD), a quassinoid found abundantly in B. javanica, to have potent cytotoxic effect on a number of pancreatic cancer cell lines, including Panc-1, SW1990 and Capan-1 cells.
Ling, Liu, Zhi-Xiu, Lin, Po Sing, Leung, Li-Hua, Chen, Ming, Zhao, Juan, Liang   +5 more
openaire   +3 more sources

A Comprehensive Review of AIM2 in Cancer: Functional Roles, Molecular Pathways, and Clinical Relevance

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Inflammation has been recognized as a component of cancer progression, and inflammasome receptor components also regulate various biological processes, including cell proliferation, gene transcription, and tumorigenesis. Accumulating evidence indicates that the AIM2 inflammasome influences tumor progression via multiple concurrent mechanisms, one of ...
Nuo Wang, Shaoxian Wu, Zhang Fang, Lujun Chen, Xiao Zheng, Poorani Gurumallesh   +5 more
wiley   +1 more source

TROP2‐guided aggregation‐induced emission‐luminogen nanoparticles overcome sacituzumab govitecan resistance via mitochondrial oxidative stress and immunogenic cell death in triple‐negative breast cancer

Interdisciplinary Medicine, Volume 3, Issue 6, November 2025.
Schematic of AIE780‐SG NPs for NIR FLI‐Guided Photo‐Enhanced Chemotherapy in Drug‐Resistant TNBC. AIE780‐SG (hRS7‐modified) targets TROP2 on TNBC cells to facilitate mitochondrial internalization. NIR illumination induces MICA/B release, recruiting and activating NK cells via MICA/B‐NKG2D and hRS7‐CD16 interactions, and enhancing secretion of cytotoxic
Nisha Wu, Shujuan Ma, Xiaohong Liu, Min Zhao, Na Sun, Rui Wang, Shanlin Huang, Minghao Sun, Ying Liu, Jun Jiang, Mengyuan Wang, Yi Zhang, Ying Gong, Xiaowei Qi   +13 more
wiley   +1 more source