Results 11 to 20 of about 350 (114)

Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2/β-catenin positive feedback loop [PDF]

Journal of Advanced Research
Introduction: Tumor-associated calcium signal transducer 2 (Trop2) has been used as a transport gate for cytotoxic agents into cells in antibody–drug conjugate designs because of its expression in a wide range of solid tumors.
Wenjuan Tang, Yu Hu, Kaihui Tu, Zhengyan Gong, Man Zhu, Tianfeng Yang, Ammar Sarwar, Bingling Dai, Dongdong Zhang, Yingzhuan Zhan, Yanmin Zhang   +10 more
doaj   +4 more sources

Brucein D suppresses breast cancer proliferation and migration via targeting the FAK/LRG1 signaling pathway [PDF]

Scientific Reports
Breast cancer (BC) is a leading cause of cancer-related mortality in women worldwide, underscoring the need for novel therapeutic strategies. Focal adhesion kinase (FAK) has emerged as a promising oncological target due to its central role in tumor ...
Lin Li, Haoyang Shen, Yu Qiu, Yan Chen, Weizhu Wu   +4 more
doaj   +6 more sources

Bruceine D may affect the phenylpropanoid biosynthesis by acting on ADTs thus inhibiting Bidens pilosa L. seed germination

Ecotoxicology and Environmental Safety, 2022
Bruceine D is a natural quassinoid, which was successfully isolated in our research group from the residue of Brucea javanica (L.) seeds. Our previous research showed that Bruceine D prevented Bidens pilosa L. seed germination by suppressing the activity
Yao Tong, Shan-Chi Yi, Shu-Yu Liu, Lin Xu, Zhuo-Xun Qiu, Dong-Qiang Zeng, Wen-Wei Tang   +6 more
doaj   +3 more sources

Bruceine D attenuates prostate cancer growth and motility by suppressing PI3K/AKT signaling and downregulating CXCL16: implications for skeletal metastasis in orthopedic oncology [PDF]

Frontiers in Pharmacology
IntroductionProstate cancer often reaches bone, which poses a challenge in orthopedic oncology since few therapies directly suppress tumor growth in bone. Bruceine D (BD) is a quassinoid from Brucea javanica.
Zhiwei Chen, Zhiwei Chen, Qingbin Huang, Qingbin Huang, Yingming Zheng, A. Garu, A. Garu, Xitao LingHu, Xitao LingHu, Wenchong Yu, Guangquan Zhao, Guangquan Zhao, Jieying Zhang, Jieying Zhang, Lin Tian, Yubo Tang, Shuai Huang, Xiaodong Zhao   +17 more
doaj   +2 more sources

Rapid Structural Analysis of Natural Products Using MicroED. [PDF]

Small
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Lin J, Paz O, Unge J, Gonen T.
europepmc   +2 more sources

Finding a Potential Bruceine D Inhibitor for Apoptotic Resistance Protein Pancreatic Cancer Based on Molecular Docking

Indonesian Journal of Chemistry, 2018
Pancreatic cancer arises when cells in the pancreas begin to multiply out of control. In pancreatic cancer, over expression of heat proteins (Hsp70, Hsp 90), constitutive activation of NFĸB, and Bcl-2 family are closely linked with resistance to ...
Armi Wulanawati, Harry Noviardi, Muhamad Sholehuddin Malik Ibrohim   +2 more
doaj   +4 more sources

Naturally Derived Terpenoids Targeting the 3D^pol of Foot-and-Mouth Disease Virus: An Integrated In Silico and In Vitro Investigation [PDF]

Viruses
Foot-and-mouth disease virus (FMDV) belongs to the Picornaviridae family and is an important pathogen affecting cloven-hoof livestock. However, neither effective vaccines covering all serotypes nor specific antivirals against FMDV infections are ...
Natjira Mana, Sirin Theerawatanasirikul, Ploypailin Semkum, Porntippa Lekcharoensuk   +3 more
doaj   +2 more sources

Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma. [PDF]

Basic Clin Pharmacol Toxicol
USP13 is a promising therapeutic target for cellular proliferation in multiple myeloma. Bruceine A can retard the development of multiple myeloma by targeting USP13/PARP1‐mediated DNA damage repair and triggering cell apoptosis. ABSTRACT Multiple myeloma (MM) is an incurable hematologic malignancy, driving significant interest in the discovery of novel
Guo M, Meng H, Sun Y, Zhou L, Hu T, Yu T, Bai H, Zhang Y, Gu C, Yang Y.   +9 more
europepmc   +2 more sources

Effect of protease inhibitors on the intraerythrocytic development of Babesia microti and Babesia duncani, the causative agents of human babesiosis. [PDF]

J Eukaryot Microbiol
Abstract Human babesiosis is a malaria‐like, tick‐borne infectious disease with a global distribution. Babesiosis is caused by intraerythrocytic, apicomplexan parasites of the genus Babesia. In the United States, human babesiosis is caused by Babesia microti and Babesia duncani.
Aderanti T, Marshall JM, Thekkiniath J.
europepmc   +2 more sources

Jiangtang Tiaozhi Formula Relieves HFD-Induced Obesity Related Type 2 Diabetes by Inhibiting the cGAS-STING Pathway. [PDF]

J Cell Mol Med
ABSTRACT Jiangtang Tiaozhi Formula (JTTZF), a traditional Chinese medicine (TCM) prescription, has been widely used clinically for obesity‐related type 2 diabetes (T2D) for many years that can clear heat, release turbidity, open up stagnation and unblock meridians.
Luo J, Min Y, Zhou L, Xiao F, Zhang X, Sun A, Zhao L, Sun D, Tong X.   +8 more
europepmc   +2 more sources