Results 31 to 40 of about 732 (170)

Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells

BMC Cancer, 2007
Background With current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulation of c-MYC is evident in numerous
Helson Lawrence, Eberhart Charles G, Stearns Duncan, Rajtarova Julia, Shalaby Tarek, von Bueren André O, Arcaro Alexandre, Grotzer Michael A   +7 more
doaj   +1 more source

Anti-tuberculosis Activity of Quassinoids.

Chemical and Pharmaceutical Bulletin, 1997
In vitro evaluation of anti-tuberculosis activity was conducted for fifty-six quassinoids isolated in our laboratory from Simaroubaceous plants, Ailanthus altissima (= Aa, 10 compounds), Brucea antidysenterica (= Ba, 16 compounds), Picrasma ailanthoides (= Pa, 14 compounds), and Brucea javanica (= Bj, 16 compounds).
RAHMAN, Shakila, FUKAMIYA, Narihiko, OKANO, Masayoshi, TAGAHARA, Kiyoshi, LEE, Kuo-Hsiung   +4 more
openaire   +3 more sources

CYTOTOXIC COMPOUND FROM ETHYL ACETATE FRACTION OF Brucea javanica (L.) Merr FRUIT AGAINST HeLa CELL LINE

Alchemy, 2015
The pure compound relatively (85 mg) was isolated from 4.5 kg Brucea javanica (L.) Merr. fruits sample. It was obtained from ethyl acetate fraction as a red-brownish amorphous solid of melting point 202-206 oC.
Nurlina Nurlina, Ari Widiyantoro
doaj   +1 more source

4,5,7,8,17-Pentahydroxy-14,18-dimethyl-6-methylene-3,10-dioxapentacyclo[9.8.0.01,7.04,19.013,18]nonadec-14-ene-9,16-dione methanol solvate dihydrate

Acta Crystallographica Section E, 2009
The title quassinoid compound, C20H24O9·CH3OH·2H2O, is a natural eurycomanone isolated from the roots of Eurycoma longifolia.
Chin Hoe Teh, Siew Chin Teoh, Chin Sing Yeap, Kit Lam Chan, Hoong-Kun Fun   +4 more
doaj   +1 more source

Targeting tumor glycolysis metabolism in oral squamous cell carcinoma cells by brusatol

Pharmacological Research - Modern Chinese Medicine, 2022
Brusatol is a natural quassinoid terpenoid that shows a potential therapeutic use in treating various ailments. Recently, brusatol was shown to have anti-tumor activity and ameliorating chemoresistance or enhancing chemotherapeutic drug efficacy in vitro
Guilian Zhang, Yanlin Wu, Suhong Chen, Ying Su, Panpan Yin, Jie Fu, Xinyan Zhang   +6 more
doaj   +1 more source

Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f. Isolamento de isobruceina B e neosergeolida de Picrolemma sprucei Hook. f. em escala-grama

Acta Amazonica, 2009
Quassinoids neosergeolide and isobrucein B, obtained from Picrolemma sprucei, have proven in vitro antitumor, antimalarial, anthelminthic, cytotoxic, insecticide and leishmanicidal activities.
Ellen Cristina Costa da Silva, Rodrigo César das Neves Amorim, Wanderli Pedro Tadei, Adrian Martin Pohlit   +3 more
doaj   +1 more source

Classification of Makasar Fruit Extract (Brucea javanica L. Merr.) Based on The Level of Ripeness Using a Combination of FTIR and UV-Vis Spectroscopy with Chemometrics

Jurnal Kimia Sains dan Aplikasi, 2023
Makasar fruit (Brucea javanica L. Merr) is a medicinal plant frequently utilized in Indonesia for its anti-malarial, anti-diabetic, antioxidant, and antibacterial properties. This research aims to classify extracts from B.
Charles Banon, Deni Agus Triawan, Morina Adfa, Monica Santa Ana Sihite, Ria Nurwidiyani, Widia Rahmi   +5 more
doaj   +1 more source

Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway

Frontiers in Pharmacology, 2017
Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities. However, the biologic mechanisms have not been fully explored.
Zheng-Quan Lai, Siu-Po Ip, Hui-Jun Liao, Zheng Lu, Zheng Lu, Jian-Hui Xie, Zi-Ren Su, Yun-Long Chen, Yan-Fang Xian, Po-Sing Leung, Zhi-Xiu Lin   +10 more
doaj   +1 more source

Synthesis of Skeleton of Antitumor Quassinoid [PDF]

Bulletin of the Chemical Society of Japan, 1988
Abstract A compound having a skeleton of an antitumor quassinoid, bruceantin, was prepared according to the following strategy; 1) construction of ring ABC from ring AB by cyclization of a hindered 1,5-diketone; 2) construction of ring E (ether ring) by opening of a 12,13-epoxide ring followed by attack of oxygen at C-20 toward C-13; 3 ...
Makoto Sasaki, Tatsushi Murae, Hisaaki Matsuo, Toshiyuki Konosu, Naoko Tanaka, Kiyoshi Yagi, Yoshinosuke Usuki, Takeyoshi Takahashi   +7 more
openaire   +1 more source

Antitumor Effect of Brusatol in Acute Lymphoblastic Leukemia Models Is Triggered by Reactive Oxygen Species Accumulation

Biomedicines, 2022
Acute lymphoblastic leukemia (ALL) is one of the most common hematological malignancies at pediatric ages and is characterized by different chromosomal rearrangements and genetic abnormalities involved in the differentiation and proliferation of lymphoid
Joana Jorge, Nisa Magalhães, Raquel Alves, Beatriz Lapa, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro   +5 more
doaj   +1 more source