Results 51 to 60 of about 732 (170)

Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway

Journal of Experimental & Clinical Cancer Research, 2022
Background Gemcitabine (GEM) is the first-line chemotherapeutic drug used to treat pancreatic ductal adenocarcinoma carcinoma (PDAC), but chemoresistance is often encountered clinically.
Juan Zhang, Hong-Xi Xu, William Chi Shing Cho, Wah Cheuk, Yang Li, Qiong-Hui Huang, Wen Yang, Yan-Fang Xian, Zhi-Xiu Lin   +8 more
doaj   +1 more source

Decoding the Chloroplast Genome of Bitterwood (Picrasma quassioides): Structure, Variability, and Evolutionary Relationships

Ecology and Evolution, Volume 15, Issue 4, April 2025.
This study reports the complete chloroplast genome of Picrasma quassioides, revealing its quadripartite structure, 132 genes, and insights into the evolution of Simaroubaceae. We identified potential molecular markers for species identification, found evidence of selective pressures, and established a robust phylogenetic framework, thereby providing ...
Qin Liu, Huaxi Huang, Jinhang Lin, Fanglin Liu, Xuexue Wang, Rong Chen, Xiaoshan Geng   +6 more
wiley   +1 more source

Efficacy and safety of Brucea javanica oil soft capsules combined with oral chemotherapy for maintenance therapy in advanced gastric cancer

Precision Medical Sciences, Volume 14, Issue 1, Page 41-45, March 2025.
Abstract The objective of this study is to compare the efficacy and safety of Brucea javanica (Yadanzi) oil soft capsules (YDZ capsules) with or without Capecitabine/S‐1 in maintenance therapy for advanced gastric cancer (GC). From January 2019 to December 2021, 105 patients treated at Jiangsu Cancer Hospital were enrolled and categorized into 3 ...
Yingying Kou, Mengting Sun, Bingxun Ling, Xianglei Ma, Wenbo Zhu, Min Zhao   +5 more
wiley   +1 more source

Effect of protease inhibitors on the intraerythrocytic development of Babesia microti and Babesia duncani, the causative agents of human babesiosis

Journal of Eukaryotic Microbiology, Volume 72, Issue 2, March/April 2025.
Abstract Human babesiosis is a malaria‐like, tick‐borne infectious disease with a global distribution. Babesiosis is caused by intraerythrocytic, apicomplexan parasites of the genus Babesia. In the United States, human babesiosis is caused by Babesia microti and Babesia duncani.
Temitope Aderanti, Jordan M. Marshall, Jose Thekkiniath   +2 more
wiley   +1 more source

PENGARUH AKAR PASAK BUMI (Eurycoma Longifolia) TERHADAP PENURUNAN KADAR SERUM GLUTAMIC OXSALOASETIC TRANSAMINASE (SGOT) DAN SERUM GLUTAMIC PYRUVIC TRANSAMINASE (SGPT) PADA TIKUS PUTIH (Rattus novergicus) YANG DIINDUKSI KARBON TETRAKLORIDA

Saintika Medika, 2017
Pengaruh Akar Pasak Bumi (Eurycoma longifolia) terhadap Penurunan Kadar Serum Glutamic Oxsaloasetic Transaminase (SGOT) dan Serum Glutamic Pyruvic Transaminase (SGPT) pada Tikus Putih (Rattus novergicus) yang Diinduksi Karbon Tetraklorida. Latar Belakang:
Dian Shiyamita, Abi Noer W, Anisa Hanifwati   +2 more
doaj   +1 more source

Phytohormones and emerging plant growth regulators in tailoring plant immunity against viral infections

Physiologia Plantarum, Volume 177, Issue 2, March/April 2025.
Abstract Viral infections are major contributors to crop yield loss and represent a significant threat to sustainable agriculture. Plants respond to virus attacks by activating sophisticated signalling cascades that initiate multiple defence mechanisms.
Kritika Shukla, Nikita, Altaf Ahmad, Md Salik Noorani, Ravi Gupta   +4 more
wiley   +1 more source

The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley rats.
Suzanah Abdul Rahman, Nur Amalina Ahmad, Nadia Hanis Abdul Samat, Syazana Zahri, Afif Raihan Abdullah, Kit-Lam Chan   +5 more
doaj   +1 more source

Mechanisms Underlying the Therapeutic Effects of Brucea javanica in Cervical Cancer Treatment Based on Network Pharmacology and Molecular Docking

International Journal of Genomics, Volume 2025, Issue 1, 2025.
Aims: The aim of this study was to systematically analyze the role of Brucea javanica in the treatment of cervical cancer (CC) and its underlying mechanisms by means of network pharmacology and molecular docking. Background:Brucea javanica is a traditional Chinese herbal medicine used for the treatment of malaria and cancers, but its mechanism of ...
Wen Jin, Bin Li, Lu Zhang, Chenyang Sun, Yiping Liu, Minghua Ren   +5 more
wiley   +1 more source

Evaluating the Antiplasmodial Activity of Picrasma javanica Stem Bark Extract and Its Synergy With Artesunate in Rodent Malaria Models

Scientifica, Volume 2025, Issue 1, 2025.
Malaria remains a global health challenge, exacerbated by the emergence of drug‐resistant Plasmodium strains. This study evaluates the antimalarial activity of Picrasma javanica stem bark extract and its combination with artesunate (ART) in Plasmodium berghei–infected mice. The extraction yield using hexane at a 1:5 (w/v) ratio was 7.8% w/w.
Sakaewan Ounjaijean, Voravuth Somsak, Simone Carradori   +2 more
wiley   +1 more source

Antiplasmodial Screening of Phikud Navakot Formulation and In Vivo Evaluation, Toxicity, and Phytochemical Profiling of the Potent Terminalia chebula Gall Aqueous Extract

Scientifica, Volume 2025, Issue 1, 2025.
The growing resistance to first‐line artemisinin‐based therapies underscores the urgent need for novel antimalarial agents, with medicinal plants offering a promising source of candidates. Phikud Navakot formulation and its component plants are widely used in traditional medicine; however, their antimalarial properties remain underexplored.
Arisara Phuwajaroanpong, Chuchard Punsawad, Prapaporn Chaniad, Atthaphon Konyanee, Abdi Wira Septama, Walaiporn Plirat, Simone Carradori   +6 more
wiley   +1 more source