Results 61 to 70 of about 732 (170)

The Nrf2/HO‐1 pathway participates in the antiapoptotic and anti‐inflammatory effects of platelet‐rich plasma in the treatment of osteoarthritis

Immunity, Inflammation and Disease, Volume 12, Issue 6, June 2024.
Study results identified a new mechanism, that is the role of Nrf2/HO‐1, underlying the protective role of platelet‐rich plasma in cartilage tissue damage in an ACLT‐induced animal model and IL‐1β‐treated chondrocytes. Meanwhile, our data provide valuable recommendations for the development of promising antiarthritic agents that act on Nrf2.
Guangyu Du, Xuegang Sun, Shengwei He, Lidong Mi   +3 more
wiley   +1 more source

Phenolic profile of unripe areca nuts cultivated in various districts of Karnataka, India

JSFA reports, Volume 4, Issue 2, Page 102-113, February 2024.
Abstract Background Annual production of areca nut in Karnataka state exceeds 1.08 million tonnes, contributing 80% and 49% to Indian and global production, respectively. Areca nut (pericarp of Areca catechu L.) is found to be a rich source of valuable phenolic compounds.
Priyanka Hugar, Ankita Dutta, S. Srilakshmi, Prasanna D. Belur, Keyur Raval, Regupathi Iyyaswami   +5 more
wiley   +1 more source

Effect of Eurycoma longifolia Stem Extract on Uric Acid Excretion in Hyperuricemia Mice

Frontiers in Pharmacology, 2019
Background:Eurycoma longifolia is a tropical medicinal plant belonging to Simaroubaceae distributed in South East Asia. The stems are traditionally used for the treatment of sexual insufficiency, fever, hypertension, and malaria.
Ruixia Bao, Mengyang Liu, Dan Wang, Shaoshi Wen, Haiyang Yu, Yi Zhong, Zheng Li, Yi Zhang, Tao Wang   +8 more
doaj   +1 more source

Bruceine E, a natural quassinoid from Brucea javanica, inhibits PARthanatos via targeting PARP1 in ischemic stroke

Frontiers in Pharmacology
Ischemic stroke currently lacks evidence-based neuroprotective agents, primarily due to the challenge of timely intervention, which often occurs after the onset of irreversible neuronal damage.
Chang Wei, Chang Wei, Chun-ze Zhai, Chun-ze Zhai, Chang-ling Yue, Chang-ling Yue, Yi-zhe Wang, Yi-zhe Wang, Yin Cao, Yin Cao, Qian-wen Yang, Qian-wen Yang, Zhao-huan Zhang, Xiao-hui Xu, Xiao-hui Xu   +14 more
doaj   +1 more source

In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants

Memorias do Instituto Oswaldo Cruz, 2007
In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae)
Valter F de Andrade-Neto, Adrian M Pohlit, Ana Cristina S Pinto, Ellen Cristina C Silva, Karla L Nogueira, Márcia RS Melo, Marycleuma C Henrique, Rodrigo CN Amorim, Luis Francisco R Silva, Mônica RF Costa, Rita CS Nunomura, Sergio M Nunomura, Wilson D Alecrim, M das Graças C Alecrim, F Célio M Chaves, Pedro Paulo R Vieira   +15 more
doaj  

Hydroxyhydroquinone and Quassinoids as Promising Compounds with Hypoglycemic Activity through Redox Balance

Compounds
In the present study, an insulin-resistant cell model (human hepatocellular carcinoma cell line: HepG2) was chosen to investigate the efficacy of two compound classes and their common molecular motif for glycemic control and insulin sensitization.
Paulo R. dos Santos, Sidinéia Danetti, A. Joseph Rastegar, Wellington V. de Souza, Rafaele Frassini, Fernando J. Scariot, Sidnei Moura, Mariana Roesch-Ely   +7 more
doaj   +1 more source

The Effect of on Sperm Quality of Male Rats

Natural Product Communications, 2009
The present study investigated the effects of a standardized methanol extract of E. longifolia Jack containing the major quassinoid constituents of 13α(21)-epoxyeurycomanone (1), eurycomanone (2), 13α,21-dihydroeurycomanone (3) and eurycomanol (4) on the
Kit-Lam Chan, Bin-Seng Low, Chin-Hoe Teh, Prashanta K. Das   +3 more
doaj   +1 more source

Nematocidal Activity of Quassinoids against a Species of Diplogastridae.

Biological and Pharmaceutical Bulletin, 2000
The nematocidal activity of 38 quassinoids, C19 or C20 compounds isolated from Simaroubaceae, was measured using a species of Diplogastridae (Nematoda) to develop lead parasiticides. Of the various quassinoids tested, samaderines B and E displayed the most potent nematocidal activity with a minimum lethal concentration (MLC) of 2.0 x 10(-5) M.
WATANABE, Ie, KOIKE, Kazuo, SATOU, Tadaaki, NIKAIDO, Tamotsu   +3 more
openaire   +3 more sources

Bruceine A alleviates lung injury in sepsis-associated acute respiratory distress syndrome by modulating macrophage polarization and NF-κB pathway activity

Pakistan Journal of Pharmaceutical Sciences
Background: Sepsis-associated acute respiratory distress syndrome (ARDS) is a severe inflammatory lung disorder with high mortality. Bruceine A (BA), a quassinoid from Brucea javanica, exhibits anti-inflammatory and immunomodulatory activities, but its ...
Jianlei Lv, Songbai Wu, Min Liu, Changsha, Hunan   +4 more
doaj   +1 more source

The Anticancer Potential of Quassinoids—A Mini-Review

Engineering
The anticancer potential of quassinoids has attracted a great deal of attention for decades, and scientific data revealing their possible applications in cancer management are continuously increasing in the literature. Aside from the potent cytotoxic and
Cai Lu, Si-Nan Lu, Di Di, Wei-Wei Tao, Lu Fan, Jin-Ao Duan, Ming Zhao, Chun-Tao Che   +7 more
doaj   +1 more source