Results 11 to 20 of about 732 (170)
Rapid Structural Analysis of Natural Products Using MicroED. [PDF]
SmallThe cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Lin J, Paz O, Unge J, Gonen T.
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Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma. [PDF]
Basic Clin Pharmacol ToxicolUSP13 is a promising therapeutic target for cellular proliferation in multiple myeloma. Bruceine A can retard the development of multiple myeloma by targeting USP13/PARP1‐mediated DNA damage repair and triggering cell apoptosis. ABSTRACT Multiple myeloma (MM) is an incurable hematologic malignancy, driving significant interest in the discovery of novel
Guo M +9 more
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Phytochemicals: Alternative for Infertility Treatment and Associated Conditions. [PDF]
Oxid Med Cell Longev, 2023 Infertility and obstetric complications have become global health issues in the past few years. Infertility is defined as the inability of a couple to conceive even after twelve months or more of regular and unprotected intercourse. According to WHO data published in the year 2020, 186 million people have infertility globally.
Chorosho SH +10 more
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BIO Web of Conferences, 2020 This study aimed to predict the proapoptosis effect of E. longifolia active compounds on prostate cancer by in silico analysis. Protein data such as BCL-2 (GI: 2506216), Caspase 3 (GI: 6978605), Caspase 8(GI: 11560103), data quassinoid (ID: 5459060 and ...
Yudha Rahman Eka +3 more
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A Concise Enantioselective Approach to Quassinoids
Journal of the American Chemical Society, 2021 A synthetic approach to quassinoids is described. The route to the tetracyclic core relies on an efficient and selective annulation between two unsaturated carbonyl components that is initiated by catalytic hydrogen atom transfer from an iron hydride to an alkene.
William P. Thomas, Sergey V. Pronin
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Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of Ailanthus altissima
Molecules, 2020 Phytochemistry investigations on Ailanthus altissima (Mill.) Swingle, a Simaroubaceae plant that is recognized as a traditional herbal medicine, have afforded various natural products, among which C20 quassinoid is the most attractive for their ...
Qing-Wei Tan +4 more
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Molecules, 2020 Brucea javanica oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially ...
Bo Kyeong Yoon +5 more
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Ecotoxicology and Environmental Safety, 2022 Bruceine D is a natural quassinoid, which was successfully isolated in our research group from the residue of Brucea javanica (L.) seeds. Our previous research showed that Bruceine D prevented Bidens pilosa L. seed germination by suppressing the activity
Yao Tong +6 more
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Plants, 2020 Species of the genus Simarouba have been studied because of their antimalarial and antileukemic activities. A group of oxygenated terpenes called quassinoids have been isolated from species of the Simarouba genus, and are responsible for its therapeutic ...
Belmari Mendez +12 more
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Recent syntheses and biological profiling of quassinoids
Organic & Biomolecular Chemistry, 2022 Quassinoids exhibit diverse biological properties and pose synthetically challenging targets. Focusing on accomplishments over the past 15 years, we discuss strategies and tactics of total syntheses as well as SAR and biological functions.
Ethan J. Pazur, Peter Wipf
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