Results 31 to 40 of about 18,319 (240)
Advanced Science, EarlyView.The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang +10 more
wiley +1 more source
Advanced Science, EarlyView.Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang +12 more
wiley +1 more source
The Case for an Autonomy-Centred View of Physician-Assisted Death [PDF]
, 2020 Most people who defend physician-assisted death (PAD) endorse the Joint View, which holds that two conditions—autonomy and welfare—must be satisfied for PAD to be justified. In this paper, we defend an Autonomy Only view.
Davis, Jeremy, Mathison, Eric
core
The Anatomical Record, EarlyView.Abstract To solidify their power over society, totalitarian regimes will usually eliminate any dissent, any perceived threats early on. These threats include not only political enemies but also educated and independent segments of society, such as professional associations.
Michael Hortsch
wiley +1 more source
An Analysis of New York State's Medical Aid in Dying Act (A. 2383A S. 3151)
Voices in Bioethics, 2018 Introduction An amended version of the proposed Medical Aid in Dying Act (A. 2383A S. 3151) was recently filed with the New York State legislature [1].
Michael Dauber
doaj +1 more source
Planning for the End of Life for People with Dementia - Part 2 [PDF]
, 2011 This publication is a discussion about additional end-of-life options which may become legally available at some time in the future, i.e., assisted death (usually called euthanasia or assisted suicide).
Colleen Cartwright
core +1 more source
Development of the Human–Equine Attachment Scale
Equine Veterinary Journal, EarlyView.Abstract Background Human–horse relationships encompass diverse roles, from companion to competition partner. The impact of such bonds informs owner decision‐making regarding horse management and veterinary care, yet standardised instruments to measure these unique bonds are limited.
Richard H. Corrigan +5 more
wiley +1 more source
Medical Students’ Attitude Towards Euthanasiain Qom in 2009
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2011 Background and Objectives: Among the major issues facing the new world of medical ethics is euthanasia. This is because euthanasia can be related to the value of human life.
A Kachoie +5 more
doaj
Moral Permissibility of Euthanasia- A Bangladesh Context
Bangladesh Journal of BioethicsSurvival is obviously important, but sometimes, under particular circumstances, life can become miserable, difficult, or intolerable; at that point, survival can seem like a punishment or misfortune.
Nilufa Yasmin
doaj +1 more source
MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen +4 more
wiley +1 more source