Results 71 to 80 of about 3,221,847 (260)
Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai +11 more
wiley +1 more source
Four Newly Established Legal Requisites for Active Euthanasia in Japan
, 1996 On March 28, 1995 at the Yokohama District Court in Japan, four legal requisites for active euthanasia were newly established by the chief judge, when he rendered the judgment on the murder case of a physician, Tokunaga. The case has been reported by the
Hoshino, Kazumasa
core
Advanced Science, EarlyView.A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky +15 more
wiley +1 more source
Advanced Science, EarlyView.Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta +10 more
wiley +1 more source
Attitude of doctors toward euthanasia in Delhi, India
Asian Journal of Oncology, 2015 Introduction: Deliberation over euthanasia has been enduring for an extended period of time. On one end, there are populaces talking for the sacrosanctity of life and on the other end, there are those, who promote individual independence.
Sheetal Singh +4 more
doaj +1 more source
Advanced Science, EarlyView.LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan +29 more
wiley +1 more source
Contemporary ethical problem - Euthanasia
Journal of Education, Health and Sport, 2019 Admission Cultural changes and more dynamic medical techniques result in a multitude of questions related to the bioethical aspects of medicine. In recent years, increased interest in the sphere of death.
Patrycja Ręba
doaj +3 more sources
The Legitimacy of Prohibiting Euthanasia
BioéthiqueOnline, 2015 ohn Arras argues against the legalization of physician- assisted suicide and active euthanasia on the basis of social costs that he anticipates will result from legalization.
Gildenhuys, Peter
doaj
Intensive Care Unit Nurses? Opinions About Euthanasia
, 2007 This study was conducted to gain opinions about euthanasia from nurses who work in intensive care units. The research was planned as a descriptive study and conducted with 186 nurses who worked in intensive care units in a university hospital, a public ...
Kumas, Gülsah +2 more
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Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source