Results 71 to 80 of about 3,376,137 (308)

Analysing restrictive and liberal approaches towards assisted suicide and euthanasia [PDF]

, 2010
MPhil (Laws)The ‘end of life’ issue in relation to assisted suicide and euthanasia is one of our prime concerns and a most widely discussed phenomenon not only in academic and official literature, but also in day-to-day life.
Matker, Prema S
core   +2 more sources

Attitudes Toward Active Voluntary Euthanasia Among Community-Dwelling Older Subjects

SAGE Open, 2018
The major extension of late-life expectancy has increased the significance of end-of-life issues, particularly among elderly people, considering both the role of medical practices in shaping and defining dying trajectories and the differences in national
Stefano Poli
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Euthanasia: Current Problems in Japan

, 1993
I hope that people in Japan soon realize that the patient's free and repeated requests for active euthanasia to his or her own physician are essential and indispensable requirements for making active euthanasia acceptable socially and legally.
Hoshino, Kazumasa
core   +1 more source

Euthanasia in the Major World Religions [PDF]

اخلاق وحیانی, 2015
“Euthanasia” or voluntary termination of life is one the most complicated issues in the moral, legal and religious debates nowadays. In the meantime, the role of religions in directing the views of researchers is obvious. In this article, a brief look at
Angeliki Ziaka
doaj  

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Voluntary Active Euthanasia and the Nurse: A Comparison of Japanese and Australian Nurses

, 2002
Although euthanasia has been a pressing ethical and public issue, empirical data are lacking in Japan. We aimed to explore Japanese nurses' attitudes to patients' requests for euthanasia and to estimate the proportion of nurses who have taken active ...
Ohnishi, Motoki, Asai, Atsushi, Fukui, Tsuguya, Yamazaki, Yasuji, Tanida, Noritoshi, Kuhse, Helga, Nagata, Shizuko K.   +6 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Four Newly Established Legal Requisites for Active Euthanasia in Japan

, 1996
On March 28, 1995 at the Yokohama District Court in Japan, four legal requisites for active euthanasia were newly established by the chief judge, when he rendered the judgment on the murder case of a physician, Tokunaga. The case has been reported by the
Hoshino, Kazumasa
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