Results 31 to 40 of about 27,160 (242)
Advanced Science, EarlyView.Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou +10 more
wiley +1 more source
Advanced Science, EarlyView.This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang +9 more
wiley +1 more source
Physician Assisted Dying as an Extension of Healing [PDF]
, 2018 The role of a physician is to provide care for those who seek their assistance. Lisa Yount attributes the most ancient statement about this activity to the Hippocratic Oath.
Marinacci, Zoe I.
core +1 more source
CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
The Case for an Autonomy-Centred View of Physician-Assisted Death [PDF]
, 2020 Most people who defend physician-assisted death (PAD) endorse the Joint View, which holds that two conditions—autonomy and welfare—must be satisfied for PAD to be justified. In this paper, we defend an Autonomy Only view.
Davis, Jeremy, Mathison, Eric
core
Medical Students’ Attitude Towards Euthanasiain Qom in 2009
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2011 Background and Objectives: Among the major issues facing the new world of medical ethics is euthanasia. This is because euthanasia can be related to the value of human life.
A Kachoie +5 more
doaj
A Critical Outlook on Rosenberg’s Theory of Euthanaisia [PDF]
Pizhūhish/hā-yi Falsafī- Kalāmī, 2017 In his book, while referring to anti-euthanasia arguments such as "prima facie right to life", "possibility of arbitrary encroachments", and "venerability of moral independence", Rosenberg draws a careful sketch of pro-euthanasia arguments including ...
Reza Akbari, Seyyed Ali Reza Hodaei
doaj +1 more source
The Anatomical Record, EarlyView.Abstract Intermittent hypobaric hypoxia (IHH) enhances oxygen transport, muscle metabolism, and cardiovascular health; however, the combined effects of hypobaria and cold are less well understood. Exposure to these stressful environmental factors, even intermittently, can affect skeletal muscle due to its plasticity, thereby altering its metabolic and ...
Garoa Santocildes +3 more
wiley +1 more source
Attitude of doctors toward euthanasia in Delhi, India
Asian Journal of Oncology, 2015 Introduction: Deliberation over euthanasia has been enduring for an extended period of time. On one end, there are populaces talking for the sacrosanctity of life and on the other end, there are those, who promote individual independence.
Sheetal Singh +4 more
doaj +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape +3 more
wiley +1 more source