Results 41 to 50 of about 628,687 (244)

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Comparison of Indonesian and Dutch Laws on the Implementation of Euthanasia

Al-Adalah
Developments in various matters cannot be separated from the regulations attached to them, one of which is related to euthanasia. Euthanasia in general is a treatment given to a patient to end his life intentionally with the aim of escaping suffering ...
Winda Fitri, Winsherly Tan, Aulia Ginda Putri   +2 more
doaj   +1 more source

The right to euthanasia: for or against?

Patologìâ, 2018
The purpose of the research is to determine the feasibility of introducing euthanasia in Ukraine based on the analysis of world experience. Euthanasia is the most controversial and ambiguous topic of scientifi research, which is on the brink of medicine
R. O. Stefanchuk, A. O. Yanchuk, M. М. Stefanchuk, M. О. Stefanchuk, N. Ye. Blazhivska   +4 more
doaj   +1 more source

Platycodon grandiflorus–Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis‐Driven Membrane Mechanical Remodeling

Advanced Science, EarlyView.
Plant‐derived nanovesicles from Platycodon grandiflorus act as bioactive lipid delivery platforms that transport γ‐linolenic acid into gastric cancer cells. This lipid cargo promotes ferroptotic lipid peroxidation, remodels membrane mechanics, and increases tumor‐cell susceptibility to cytotoxic T‐cell attack.
Jian Wu, Ruijuan Zhang, Yixin Duan, Shuqi Huo, Xiang Zhang, Yibin Xing, Lingjing Ma, Tiran Jiang, Xingyu Chen, Qingmin Sun   +9 more
wiley   +1 more source

Euthanasia in the Major World Religions [PDF]

اخلاق وحیانی, 2015
“Euthanasia” or voluntary termination of life is one the most complicated issues in the moral, legal and religious debates nowadays. In the meantime, the role of religions in directing the views of researchers is obvious. In this article, a brief look at
Angeliki Ziaka
doaj  

Physician-assisted suicide and euthanasia in Indian context: Sooner or later the need to ponder!

Indian Journal of Psychological Medicine, 2013
Physician-assisted suicide (PAS) is a controversial subject which has recently captured the interest of media, public, politicians, and medical profession.
Farooq Khan, George Tadros
doaj   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Attitude of undergraduate medical students towards euthanasia and physician-assisted suicide: a cross-sectional study

Journal of the Pakistan Medical Association
Euthanasia is categorically prohibited in Pakistan by Islamic law, but a clash of opinions among doctors and human rights advocates still prevails. As a result, medical students are becoming concerned about its practice and this problem needs to be ...
Mahnoor, Aiza Noor Shahid, Haleema Shafiq, Noman Aslam, Ayesha Ayub   +4 more
doaj   +1 more source

WITHDRAWING TREATMENT AND KILLING: THE WAYS TO DISTINGUISH

Вісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетії, 2020
One of the key problems facing bioethics concerns those cases where, due to the limited human and technical resources of medicine, patients are in fact doomed to die.
Kateryna S. Rassudina
doaj   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source