Results 61 to 70 of about 8,256 (183)

Oesophageal Epithelial Cell‐Intrinsic MHCII Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an IFNγ‐Dependent Manner

Clinical &Experimental Allergy, EarlyView.
We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ‐inducible transcriptional elements. EEC‐intrinsic MHCII promoted regulatory T cell accumulation and attenuated eosinophilic oesophageal inflammation.
Eric M. Rodríguez‐López, Rachel L. Clement, Megha Lal, Yusen Zhou, Stephen D. Carro, Charles‐Antoine Assenmacher, Ravi Gautam, Jarad Beers, Amanda B. Muir, Jonathan M. Spergel, Melanie A. Ruffner, Laurence C. Eisenlohr, David A. Hill   +12 more
wiley   +1 more source

Problem uporczywej terapii w świetle filozofii człowieka

Studia Ecologiae et Bioethicae, 2009
The problem of medical futility, which combines the issues of euthanasia, is one of the most difficult matter of medical ethics. The theraphy becomes futile when a patient is in an agonizing state and none of the extraordinary actions can restore the ...
Kazimierz Szałata
doaj   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

A Case for Contingent Absurdity

European Journal of Philosophy, EarlyView.
Abstract A popular view on existential absurdity holds that if life is absurd, it must be inescapably so. In opposition to this view, I argue that the concept of existential absurdity allows for life to be contingently absurd. In Nausea (1938) and Being and Nothingness (1943), Jean‐Paul Sartre puts forward two distinct conceptions of an absurd life ...
Thom Hamer
wiley   +1 more source

Equine botulism

Equine Veterinary Journal, EarlyView.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik, Robert Whitlock, Amy Johnson   +2 more
wiley   +1 more source

Prevalence and Implications of “Must‐Kill” Angling Regulations for the Management of Invasive Fishes

Fisheries Management and Ecology, EarlyView.
ABSTRACT Freshwater biodiversity is increasingly threatened by invasive species, which can disrupt native fish populations and the fisheries they support. Must‐kill regulations, which prohibit the live release of invasive fish caught by recreational anglers, are a management strategy that can be implemented to limit the negative effects of invasive ...
Kevin A. Adeli, Bryan D. Neff, Steven J. Cooke   +2 more
wiley   +1 more source

Passive Euthanasia: A Right Choice?

, 2022
The word "euthanasia" is derived from the Greek words "Eu’’ and "Thanatos," which means "Good Death"." Passive euthanasia can be termed as intentionally letting a patient die by withholding artificial life support such as a ventilator or feeding tube.
openaire   +1 more source

Educational Strategies for Managing Moral Distress in Student Nurses: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To explore what content, teaching and learning activities are advocated by nurse educators to mitigate moral distress and related concepts in student nurses. Design Scoping review. Review Methods The review was conducted according to Joanna Briggs Institute guidelines.
Rebecca Timmins, Chris Kite
wiley   +1 more source

An Ethical Review of Euthanasia and Physician-assisted Suicide

Iranian Journal of Public Health, 2017
Background: In the majority of countries, active direct euthanasia is a forbidden way of the deprivation of the patients’ life, while its passive form is commonly accepted.
Božidar BANOVIĆ, Veljko TURANJANIN, Anđela MILORADOVIĆ   +2 more
doaj  

French parliamentary committee advocates passive euthanasia [PDF]

BMJ, 2004
Doctors' associations in France have welcomed a report by a parliamentary committee recommending that passive euthanasia should be allowed. In a landmark report, the cross party committee of 31 deputies recommended that terminally ill patients should be given the right to refuse treatment in certain circumstances.
openaire   +1 more source