Results 111 to 120 of about 145,438 (302)

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Euthanasia: Current Problems in Japan

, 1993
I hope that people in Japan soon realize that the patient's free and repeated requests for active euthanasia to his or her own physician are essential and indispensable requirements for making active euthanasia acceptable socially and legally.
Hoshino, Kazumasa
core   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Key challenges in providing assisted dying in Belgium: a qualitative analysis of health professionals’ experiences

Palliative Care and Social Practice
Background: Assisted dying or ‘euthanasia’ has been legal in Belgium since 2002. Extensive research has been conducted which investigates Belgian euthanasia practice, however, the current challenges that health professionals face when providing ...
Madeleine Archer, Lindy Willmott, Kenneth Chambaere, Luc Deliens, Ben P. White   +4 more
doaj   +1 more source

Euthanasia and the Healthcare Professional

, 1995
Euthanasia, often called mercy killing, is the act of inducing death often on terminally ill individuals for reasons assumed to be merciful. Euthanasia can be active or passive, and voluntary or involuntary.
Nnadi-Okolo, Eucharia E.
core  

Due care in the context of euthanasia requests by persons with psychiatric illness : lessons from a recent criminal trial in Belgium

, 2023
Belgium is one of very few countries where euthanasia on the basis of psychiatric illness is legally possible. Three physicians involved in the euthanasia of a 38-year-old woman suffering from psychiatric illness recently faced a criminal trial for ...
De Hert, Marc, Sterckx, SigridLW018010009981470000-0003-1018-1127F4DFEBE6-F0ED-11E1-A9DE-61C894A0A6B4, Varelius, Jukkaeditor, Cholbi, Michaeleditor, Van Assche, Kristof   +4 more
core  

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Euthanasia: A Contemporary Moral Quandary

, 1989
Responding to an increased interest in establishing active, voluntary euthanasia as a viable medical and social policy, Reichel and Dyck consider the major arguments for and against the practice.
Dyck, Arthur J., Reichel, William
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Perceptions of swine euthanasia among Brazilian caretakers from non-integrated swine farms

Frontiers in Veterinary Science
Timely and humane euthanasia is crucial for animal welfare on swine farms, yet challenges persist in its implementation, particularly in Brazil, where the responsibility often falls to caretakers lacking training. This study aimed to assess the knowledge,
Laya Kannan Silva Alves, Laya Kannan Silva Alves, Monique Danielle Pairis-Garcia, Andréia Gonçalves Arruda, Cecília Archangelo Ferreira de Melo, Nadia de Almeida Ciriaco Gomes, Roberta Yukari Hoshino, Cesar Augusto Pospissil Garbossa   +7 more
doaj   +1 more source