Results 111 to 120 of about 119,088 (258)

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Physicians' Attitudes Toward Euthanasia in Türkiye: A Cross-Sectional Survey of Ethical Heterogeneity and Decision-Making Patterns. [PDF]

Healthcare (Basel)
Aydogan HC, Arslan HG, Yaşar Teke H.
europepmc   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Factors Influencing Decision-Making in Companion Animal Euthanasia: A Mixed-Methods Study of Pet Owners and Veterinarians. [PDF]

Animals (Basel)
Kiss A, Möller W, Wagenhoffer Z, Fodor K.   +3 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Euthanasia in advanced dementia: an empirical study of the decision-making process based on advance directives. [PDF]

Age Ageing
Coers DO, Ronde B, Sizoo EM, Hertogh CMPM, Smalbrugge M, Leget CJW, de Boer ME.   +6 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

A scoring system for euthanasia decisions in rescued raccoon dogs (Nyctereutes procyonoides): Standardized criteria in wildlife rehabilitation. [PDF]

PLoS One
Kim BK, Eo SH.
europepmc   +1 more source

Non‐Line‐of‐Sight Passive Ammonia Sensor Loaded With MXene/In2O3 Composites for Agricultural Products Quality Deterioration Detection

Advanced Science, EarlyView.
This study presents a flexible, battery‐free passive RFID sensing platform for NLoS monitoring of quality deterioration in fresh agricultural products. It utilizes a structurally decoupled spiral antenna‐LC electrode architecture to suppress electromagnetic interference caused by packaging.
Guoping Hu, Lin He, Fanli Meng, Daming Dong, Guolong Shi   +4 more
wiley   +1 more source

Finnish physicians' attitudes towards euthanasia and physician-assisted suicide: a nationwide cross-sectional study. [PDF]

BMJ Open
Piili RP, Tolvanen E, Hökkä M, Vänskä J, Louhiala P, Lehto JT.   +5 more
europepmc   +1 more source