Results 11 to 20 of about 3,381 (135)

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Evaluation of therapeutic effects of D‐limonene following orchiopexy in the rat model of cryptorchidism

Animal Models and Experimental Medicine, EarlyView.
D‐limonene supplementation enhances testicular recovery following orchiopexy in a rat model of bilateral cryptorchidism. Treatment with D‐limonene reduces oxidative stress (↓MDA, ↑SOD, ↑GPx, ↑TAC), downregulates pro‐apoptotic proteins (↓TNF‐α, ↓BAX, ↓Caspase‐3), and upregulates anti‐apoptotic Bcl‐2 expression.
Arman Norouzi‐Ghalehbala, Mohammadjavad Rezaei‐Varmaziar, Majid Taati, Ali Soleimanzadeh, Abbas Raisi, Farshid Davoodi, Amir Ali Shahbazfar   +6 more
wiley   +1 more source

Emotional responses of veterinary students to first encounters with animal body donors

Anatomical Sciences Education, EarlyView.
Abstract Students' first encounters with animal body donors in higher education are a formative and also potentially stressful experience. The complex emotions elicited by body donor use in learning and their effects on professional development have been documented in medical students, but are far less explored in veterinary medical counterparts.
S. Regnault, C. Basu, S. Channon
wiley   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Impact of evidence‐based information on horse owners' misconceptions of colic

Equine Veterinary Journal, EarlyView.
Abstract Background Misconceptions can be defined as ‘false, persistent beliefs’ or ‘inaccurate, prior knowledge’ and can influence decision‐making. Objectives To investigate the impact of evidence‐based information on UK horse owners' decision‐making for colic. Study Design Mixed‐methods cross‐sectional study.
K. L. Burrell, G. C. W. England, J. H. Burford, S. L. Freeman   +3 more
wiley   +1 more source

Accomplishing Ethics‐Work as a Generic Social Process

Symbolic Interaction, EarlyView.
Existing systems of university research ethics are often criticized by those in the qualitative research tradition. A common thread is that ethics cannot be fully anticipated before the research begins, as is expected by most institutional review boards.
Deana Simonetto, Antony Puddephatt
wiley   +1 more source

Associations between transformational leadership, occupational stress and emotional exhaustion in UK veterinary professionals: A cross‐sectional study

Veterinary Record, EarlyView.
Abstract Background Occupational stress and burnout are prevalent concerns within the UK veterinary profession. Within the job demands–resources (JD‐R) framework, occupational stress represents a job demand linked to emotional exhaustion (EE), while transformational leadership (TL) may function as an organisational resource.
Roanneth Slater‐Brown
wiley   +1 more source

Why do Public Debates Escalate? Trigger Points and the Moral Dynamics of “Hot Politics”

The British Journal of Sociology, EarlyView.
ABSTRACT Escalating, emotionally charged, and moralized forms of controversy are a central feature of contemporary politics. Our study develops a framework for understanding how political debates between ordinary citizens become heated; why certain issues provoke particularly strong emotions; and how this affective potential is weaponized by ...
Linus Westheuser, Thomas Lux, Steffen Mau   +2 more
wiley   +1 more source