Results 51 to 60 of about 52,223 (297)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Deep reinforcement learning and 3D physical environments applied to crowd evacuation in congested scenarios

International Journal of Digital Earth, 2023
To avoid crowd evacuation simulations depending on 2D environments and real data, we propose a framework for crowd evacuation modeling and simulation by applying deep reinforcement learning (DRL) and 3D physical environments (3DPEs).
Dong Zhang, Wenhang Li, Jianhua Gong, Guoyong Zhang, Jiantao Liu, Lin Huang, Heng Liu, Haonan Ma   +7 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Agent-Based Evacuation Modeling: Enhancing Building Safety in Emergency Scenarios

Smart Cities
Buildings and their supporting infrastructure are vulnerable to both natural and human-made disasters, which pose significant risks to the safety of the occupants.
Miguel Islas-Toski, Erik Cuevas, Marco Pérez-Cisneros, Héctor Escobar   +3 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Development Of Planning Support System For Urban Rehabilitation And Reconstruction In Case Sidoarjo Mud Flow Post Disaster [PDF]

, 2011
Sidoarjo mud disaster impact that has lasted more than 3 years are very influential on other aspects of life in Porong and surrounding areas. The need for information systems that can inform the public about the catastrophic conditions is absolutely ...
Arna, Fariza, M. Syamsul, Hudha, Muhamad, Bayu AS, Rosita, Vebriesti Ratri, Wahjoe, Tjatur Sesulihatien   +4 more
core  

Multi-agent simulations for emergency situations in an airport scenario [PDF]

, 2012
This paper presents a multi-agent framework using Net- Logo to simulate humanand collective behaviors during emergency evacuations. Emergency situationappears when an unexpected event occurs.
Bicharra García, Ana Cristina, Correia, Luis, Molina, José M., Sánchez-Pi, Nayat   +3 more
core   +6 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Spatial Modeling of Cold Lava Flood Evacuation in Kali Putih, Magelang Regency, Using Network Analyst [PDF]

, 2018
The event of Mount Merapi\u27s phreatic eruption, at least reminds us that the riverbank of Kali Putih which is located in Magelang Regency, Central Java Province has not been completely free from the threat of cold lava flood, especially during the ...
Trenggana, S. (Soma)
core