Results 61 to 70 of about 52,223 (297)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Fault tree analysis for subway fire evacuation with agent-based modeling

Journal of Infrastructure Preservation and Resilience, 2023
In the process of the continuous development of subway construction, the safe evacuation of subway passengers has been paid much attention to. As the subway itself has the characteristics of limited space and high passenger density, once a fire emergency
Yaning Qiao, Yikai Weng, Xiaobo Shi, Zongyou Zhu, Changyun Li, Xumiao Zhang, Jiankun Liu   +6 more
doaj   +1 more source

An extended car following approach using agent based model on evacuation system of micro traffic [PDF]

, 2009
We proposed an extended car-following approach on evacuation system of micro traffic. It is based on the agent model. Parameter which is owned by the agent is the velocity.
Harsono, Tri
core  

Design of evacuation plans for densely urbanised city centres [PDF]

, 2016
The high population density and tightly packed nature of some city centres make emergency planning for these urban spaces especially important, given the potential for human loss in case of disaster. Historic and recent events have made emergency service
Jesus, Eduardo Natividade, Rodrigues, João Coutinho, Sousa, Nuno   +2 more
core   +1 more source

Human Evacuation Modeling

, 2012
The modeling of movement patterns of human crowds at the exit point of an enclosed space is a complex and challenging problem. In a densely populated space, if all the occupants are simultaneously rushing for the exits, shuffling, pushing, crushing and trampling of people in the crowd may cause serious injuries and even loss of lives.
Stephen Wee Hun Lim, Eldin Wee Chuan Lim
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Simulation of Running Crowd Dynamics: Potential-Based Cellular Automata Model

IEEE Access, 2023
Running is often accompanied by fear or panic during emergency evacuation, and the evacuation of pedestrian crowds at different speeds poses additional challenges in terms of modeling and simulation. To investigate the fundamental interference of running
Tao Yu, Hai-Dong Yang
doaj   +1 more source

Modified ACO Evacuation Model Based On Evacuation Entropy

IOP Conference Series: Materials Science and Engineering, 2018
Since the existing crowd evacuation model for path optimization problems seldom considers the degree of confusion in the crowd movement, a modified Ant Colony Optimization (ACO) evacuation model based on evacuation entropy is constructed in this paper. Evacuation entropy reflects the degree of crowd confusion.
Fang Wang, Jian Wang, Xiaowei Chen
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source