Results 71 to 80 of about 105,097 (295)

Fire Evacuation for People with Functional Disabilities in High-Rise Buildings: A Scoping Review

Buildings
Fire emergencies pose significant risks to occupants in high-rise buildings, particularly individuals with functional limitations who struggle with conventional evacuation facilities like stairs.
Yimiao Lyu, Hongchun Wang
doaj   +1 more source

Network Modeling of Hurricane Evacuation Using Data-Driven Demand and Incident-Induced Capacity Loss Models

Journal of Advanced Transportation, 2021
The development of a hurricane evacuation simulation model is a crucial task in emergency management and planning. Two major issues affect the reliability of an evacuation model: one is estimations of evacuation traffic based on socioeconomic ...
Yuan Zhu, Kaan Ozbay, Kun Xie, Hong Yang, Ender Faruk Morgul   +4 more
doaj   +1 more source

Capacity Based Evacuation with Dynamic Exit Signs

, 2013
Exit paths in buildings are designed to minimise evacuation time when the building is at full capacity. We present an evacuation support system which does this regardless of the number of evacuees.
Desmet, Antoine, Gelenbe, Erol
core   +1 more source

Key challenges in agent-based modelling for geo-spatial simulation [PDF]

, 2007
Agent-based modelling (ABM) is fast becoming the dominant paradigm in social simulation due primarily to a worldview that suggests that complex systems emerge from the bottom-up, are highly decentralised, and are composed of a multitude of heterogeneous ...
Batty, M, Castle, C, Crooks, A
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Data-driven mathematical simulation analysis of emergency evacuation time in smart station's operations management.

PLoS ONE
This research establishes an emergency evacuation time model specifically designed for subway stations with complex structures. The model takes into account multiple factors, including passenger flow rate, subway facility parameters, and crowd density ...
Yang Hui, Qiang Yu, Hui Peng
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Modeling pedestrian evacuation movement in a swaying ship

, 2015
With the advance in living standard, cruise travel has been rapidly expanding around the world in recent years. The transportation of passengers in water has also made a rapid development.
AH Olivier, AI Ginnis, D Helbing, ER Galea, J Ma, W Daamen   +5 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Modelling the Effect of Smoke on Evacuation Strategies in Hospital Buildings

Buildings
Designing fire evacuation strategies for hospitals involves navigating complex infrastructure and accommodating the unique needs of patients, many of whom may have limited mobility or require specialized support during emergencies.
Ankush Jha, Nizar Lajnef, Venkatesh Kodur   +2 more
doaj   +1 more source