Results 101 to 110 of about 8,166,444 (292)

Insights into the burden of bacterial antimicrobial resistance (AMR) in the WHO Eastern Mediterranean Region: a crucial step towards evidence-informed and targeted public health interventions

International Journal of Infectious Diseases
Introduction: Antimicrobial resistance (AMR) is a significant but very complex global health issue, making it difficult to accurately determine its full impact.
Dr. Tomislav Mestrovic, Dr Gisela Robles Aguilar, Mr Lucien R Swetschinski, Mrs Nicole Davis Weaver, Mrs Eve E Wool, Mrs Authia P Gray, Prof Kevin S Ikuta, Mr Chieh Han, Mrs Anna Gershberg Hayoon, Prof Erin Chung, Prof Simon I Hay, Prof Christiane Dolecek, Prof Benn Sartorius, Prof Christopher J L Murray, Prof Mohsen Naghavi   +14 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Criteria and practical guidance for determination of brain death in adults (BQCC version)

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
DOI: 10.3969/j.issn.1672-6731.2015.12 ...
Brain Injury Evaluation Quality Control National Health and Family Planning Commission
doaj  

Navigating emotions, communication, and pain during prehospital labour: a mixed-methods survey with emergency ambulance services

BMC Emergency Medicine
Introduction Despite their crucial role in prehospital obstetric emergencies, there is little research exploring emergency medical service (EMS) personnel’s perspectives and attitudes on out-of-hospital births, including balancing the numerous needs of ...
Vinuli Withanarachchie, Verity Todd, Bridget Dicker, Sarah E. Maessen   +3 more
doaj   +1 more source

Monoclonal antibodies: Development of universal (platform) methods for the assessment of high and low-molecular weight impurities

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The development of unified techniques for quality control monoclonal antibodies (mAb) is one of the challenges for mAbs quality standardization.AIM.
O. A. Vaganova, R. S. Smirnov, S. A. Lenin, K. S. Funtashev, A. A. Kostromskih, A. S. Peregudova, D. A. Kadykova, V. A. Merkulov   +7 more
doaj   +1 more source

An Independent Evaluation

, 2015
The year 2015 is pivotal in international development. As the era of the Millennium Development Goals (MDGs) concludes, work continues to take forward the unfinished MDG agenda and to define and meet the
Independent Evaluation Group
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Evaluation planning in program initiatives [PDF]

, 2004
French version available in IDRC Digital Library: Planification de l'évaluation dans les initiatives de ...
IDRC. Evaluation Unit
core