Results 121 to 130 of about 8,166,444 (292)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The in vivo revolution in CAR-T therapy medicinal products: challenges and regulatory prospects

Signal Transduction and Targeted Therapy
Chimeric antigen receptor T-cell (CAR-T) therapy, a groundbreaking advancement in cancer immunotherapy, has demonstrated remarkable efficacy in treating hematological malignancies and autoimmune diseases.
Jiaqi Lu, Jing Cui, Jing Dong, Liping Yan, Xue Wang, Di Zhou, Shuang Lu, Wei Wei   +7 more
doaj   +1 more source

Evaluation of the World Bank Group Program

, 2014
IEG’s Country Program Evaluation (CPE) covers the period FY05–13. The period spans three World Bank Group country strategies and one progress report. It also covers the last years of the Ben Ali regime and the
Independent Evaluation Group
core  

Annual corporate evaluation report 1994 [PDF]

, 1994
French version available in IDRC Digital Library: Rapport annuel sur l'évaluation au Centre ...
IDRC. Evaluation Unit
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Analysis of a sociological survey on information and educational needs of specialists in the field of medicines circulation as regards the issue of medicines interchangeability

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article summarises the results of a 2015 survey of healthcare professionals and pharmacists that was aimed to reveal their educational needs on the subject of interchangeable medicines.
N. G. Goloenko, R. I. Yagudina, B. K. Romanov, R. N. Alyautdin, D. G. Karapetyan, E. G. Zelenova, E. E. Arinina, A. Yu. Kulikov, M. V. Protsenko, G. T. Abdrashitova   +9 more
doaj  

Annual corporate evaluation report 2005 [PDF]

, 2005
French version available in IDRC Digital Library: Rapport annuel sur l'évaluation ...
IDRC. Evaluation Unit
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Annual corporate evaluation report 1998 [PDF]

, 1998
French version available in IDRC Digital Library: Rapport annuel sur l'évaluation ...
IDRC. Evaluation Unit
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source