Results 131 to 140 of about 15,954,475 (309)

Pharmacogenetic testing in the treatment of type 2 diabetes with sulfonylurea drugs

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article analyses scientific literature on the use of pharmacogenetic testing to optimize sulfonylurea treatment of patients with type 2 diabetes.
G. I. Gorodetskaya, V. G. Kukes, S. A. Belkov, R. E. Kazakov, S. Yu. Serebrova, O. V. Muslimova, T. A. Rodina, A. A. Aleksandrov   +7 more
doaj  

Optimal allocation of antenatal and young child nutrition interventions: an individual-based global burden of disease calibrated microsimulation

BMC Global and Public Health
Background Undernutrition remains a global crisis and is a focus of Sustainable Development Goals. While there are multiple known, effective interventions, complex interactions between prevention and treatment and resource constraints can lead to ...
Alison Bowman, Sylvia Lutze, James Albright, Nathaniel Blair-Stahn, Hussain Jafari, Simar Kaur, Caroline Kinuthia, Rajan Mudambi, Patrick Nast, Alix Pletcher, Abraham Flaxman   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Recombinant zoster vaccine is associated with a reduced risk of dementia

Nature Communications
Vaccines to prevent herpes zoster have been associated with reduced dementia risk. We conducted a retrospective matched cohort study of Kaiser Permanente Southern California members aged ≥65 years who received two doses of RZV 4 weeks–6 months apart ...
Emily Rayens, Lina S. Sy, Lei Qian, Bradley K. Ackerson, Julia Tubert, Yi Luo, Punam P. Modha, Raul O. Calderon, Elizabeth Chmielewski-Yee, Driss Oraichi, Huifeng Yun, Carol Koro, Hung Fu Tseng   +12 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Evaluating ‘evaluation’ [PDF]

Practice Development in Health Care, 2008
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Interchangeability of glibenclamide-containing drugs

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article analyses the problem of interchangeability of glibenclamide-containing drugs that sometimes lack therapeutic equivalence even though their bioequivalence has been proven.
G. I. Gorodetskaya, E. V. Shikh, M. V. Zhuravleva, S. Yu. Serebrova, E. A. Sokova, O. V. Muslimova, T. V. Aleksandrova, I. A. Mazerkina, S. G. Rudnev   +8 more
doaj  

Pharmacoeconomics: evaluating the evaluators [PDF]

British Journal of Clinical Pharmacology, 1997
A, Haycox, T, Walley
openaire   +2 more sources