Results 61 to 70 of about 17,544,570 (361)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Trends and patterns of disparities in diabetes and chronic kidney disease mortality among US counties, 1980–2014

Population Health Metrics, 2022
Introduction Diabetes and chronic kidney diseases are associated with a large health burden in the USA and globally. Objective To estimate age-standardized mortality rates by county from diabetes mellitus and chronic kidney disease.
Ali H. Mokdad, Laura Dwyer-Lindgren, Amelia Bertozzi-Villa, Rebecca W. Stubbs, Chloe Morozoff, Shreya Shirude, Sam B. Finegold, Charlton Callender, Mohsen Naghavi, Christopher J. L. Murray   +9 more
doaj   +1 more source

Evaluating the evaluation system

Kathmandu University Medical Journal, 1970
DOI: 10.3126/kumj.v8i1.3212 Kathmandu University Medical Journal (2010), Vol. 8, No.
openaire   +4 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Navigating emotions, communication, and pain during prehospital labour: a mixed-methods survey with emergency ambulance services

BMC Emergency Medicine
Introduction Despite their crucial role in prehospital obstetric emergencies, there is little research exploring emergency medical service (EMS) personnel’s perspectives and attitudes on out-of-hospital births, including balancing the numerous needs of ...
Vinuli Withanarachchie, Verity Todd, Bridget Dicker, Sarah E. Maessen   +3 more
doaj   +1 more source

Evaluating how we evaluate [PDF]

Molecular Biology of the Cell, 2012
Evaluation of scientific work underlies the process of career advancement in academic science, with publications being a fundamental metric. Many aspects of the evaluation process for grants and promotions are deeply ingrained in institutions and funding agencies and have been altered very little in the past several decades, despite substantial ...
openaire   +4 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Elevated glucagon and postprandial hyperglycemia in fatty liver indicate early glucose intolerance in metabolic dysfunction associated steatotic liver disease

Scientific Reports
In Japan, fatty liver cases with elevated body mass index are increasing. Because of being non-malignant, these are often neglected unless accompanied by diabetes.
Rieko Oikawa, Yumiko Nakanishi, Keiji Fujimoto, Asako Wakasa, Mizuho Iwadare, Haruka Kawanami Iwao, Ryoko Ishida, Kunimitsu Iwai   +7 more
doaj   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source