Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Establishment of a value evaluation system for health and wellness tourism resources: Reflections on China's official tourism resource evaluation criteria. [PDF]
PLoS One, 2023 Zhou M +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Assessment of Environmental Sustainability and Stability of Crop Production Technological Processes
Инженерные технологии и системыIntroduction. The increased anthropogenic impact of technological tools leads to a violation of the environmental sustainability and stability of crop production technological processes that has a negative effect on the existing agrarian landscape ...
Nozim I. Jabborov +2 more
doaj +1 more source
Correction: Evaluation Criteria for Weight Management Apps: Validation Using a Modified Delphi Process. [PDF]
JMIR Mhealth Uhealth, 2023 Robles N +9 more
europepmc +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Introducing a New Concept in the Theory of Integrated Forensic Investigation
Теория и практика судебной экспертизы, 2014 The paper addresses some issues arising from the need to evaluate new theories andconcepts, presents key innovative aspects of the recently developed theory of integratedforensic investigation and highlights the synthesis of the existing and new ...
L. G. Edzhubov +3 more
doaj
Circulating tumor DNA: Response Evaluation Criteria in Solid Tumors - can we RECIST? Focus on colorectal cancer. [PDF]
Ther Adv Med Oncol, 2023 Spindler KG, Jakobsen A.
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Modified quantitative and volumetric response evaluation criteria for patients with hepatocellular carcinoma after transarterial chemoembolization. [PDF]
Front Oncol, 2023 Xu J +7 more
europepmc +1 more source