Results 101 to 110 of about 6,199,232 (247)
BMC Global and Public HealthBackground Rheumatic heart disease (RHD) disproportionally affects young populations in socio-economically disadvantaged settings, resulting in a skewed distribution towards low- and middle-income countries.
Megan Lindstrom +9 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Evaluation Criteria for Human-Automation Performance Metrics
, 2008 Previous research has identified broad metric classes for human-automation performance to facilitate metric selection, as well as understanding and comparison of research results. However, there is still lack of an objective method for selecting the most
Patricia E. Pina +5 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
BMJ Public HealthIntroduction While estimates of donor-provided resources for maternal health and family planning are readily available, government and household spending on these activities is limited.
Joseph L Dieleman +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Annual report on evaluation findings 2001 [PDF]
, 2001 French version available in IDRC Digital Library: Rapport annuel sur les constatations des évaluations 2001Section I presents findings from the IDRC Evaluation Unit (2000-2001) drawn from 15 evaluations with specific attention to three areas of program ...
IDRC. Evaluation Unit
core
The Lancet Public HealthSummary: Background: Sex and gender shape health. There is a growing body of evidence focused on comprehensively and systematically examining the magnitude, persistence, and nature of differences in health between females and males.
Vedavati Patwardhan, PhD +13 more
doaj +1 more source