Results 61 to 70 of about 2,025,466 (207)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Recent Advancements in Topic Modeling Techniques for Healthcare, Bioinformatics, and Other Potential Applications

open access: yesAdvanced Intelligent Systems
In today's era of enormous text data, topic modeling is emerging as a revolutionary tool in natural language processing. From the corpus of scientific research articles to social media posts and newspaper headlines, topic modeling is employed in several ...
Pratima Kumari   +6 more
doaj   +1 more source

Causal Inference Through Potential Outcomes and Principal Stratification: Application to Studies with "Censoring" Due to Death

open access: yes, 2006
Causal inference is best understood using potential outcomes. This use is particularly important in more complex settings, that is, observational studies or randomized experiments with complications such as noncompliance.
Rubin, Donald B.
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Updates on placental studies in bitches [PDF]

open access: yesCiência Rural
: The placenta, despite being a temporary organ, is essential for the development and survival of the conceptus. During pregnancy, it performs essential functions, such as nutrition, protection, circulation, excretion, and secretion.
Sarah Fernanda Salgado Tavares Farias   +1 more
doaj   +1 more source

Spatial-Temporal Topic Model for Cold-Start Event Recommendation

open access: yesIEEE Access, 2020
Event recommendation has attracted an increasing attention with the popularity of event-based social networks (EBSNs). The previous studies mainly focus on exploiting various contextual information to alleviate the cold-start problem in event ...
Ruichang Li   +3 more
doaj   +1 more source

Evaluating epistemic uncertainty under incomplete assessments [PDF]

open access: yes, 2007
The thesis of this study is to propose an extended methodology for laboratory based Information Retrieval evaluation under incomplete relevance assessments.
Barry   +25 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Simulation technology use in disaster medicine education and training: a scoping review

open access: yesFrontiers in Disaster and Emergency Medicine
BackgroundDisaster medicine (DM) education has increasingly turned to simulation technologies to address the limitations of traditional training methods.
José García Ulerio   +10 more
doaj   +1 more source

Embedding Diversity: Communication and Label Concept for Underutilized Crops – Checklist for your First Evaluation [PDF]

open access: yes, 2018
There are some very successful cases of marketing of underutilized crops in European countries. Examples are the marketing of rare varieties in Austrian and Swiss supermarkets.
Förster, Iris   +2 more
core  

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