Results 41 to 50 of about 56,879 (225)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs

The Anatomical Record, EarlyView.
Abstract Brachycephaly in domestic rabbits is increasingly perceived by welfare organizations as associated with significant health complications, particularly oral pathologies. Despite this perception, comparative anatomical research into rabbit brachycephaly is limited compared to that of dogs and cats, compelling an in‐depth examination of its ...
Helaina Cressy, Alice Nishigaki, Matthew C. Gage, Renato L. Previdelli   +3 more
wiley   +1 more source

Complications of Evans' syndrome in an infant with hereditary spherocytosis: a case report

Journal of Hematology & Oncology, 2009
Hereditary spherocytosis (HS) is a genetic disorder of the red blood cell membrane clinically characterized by anemia, jaundice and splenomegaly. Evans' syndrome is a clinical syndrome characterized by autoimmune hemolytic anemia (AIHA) accompanied by ...
Kuwana Masataka, Oyamada Takashi, Yoshihara Takao, Ishida Hiroyuki, Yoshida Hideki, Imamura Toshihiko, Morimoto Akira   +6 more
doaj   +1 more source

Massive Right Chylothorax Secondary to a Severe Systemic Lupus Erythematosus Flare With Secondary Evans Syndrome: A Case Report and Literature Review

Clinical Medicine Insights: Case Reports, 2023
This case report describes a 23-year-old male patient who presented with right chylothorax as the initial manifestation of a severe flare of systemic lupus erythematosus (SLE) and secondary Evans syndrome.
David Corredor-Orlandelli, Andrés Arévalo-Romero, Carlos Reyes, Dylan Arango   +3 more
doaj   +1 more source

Post-splenectomy Posterior Reversible Encephalopathy Syndrome in a β-Thalassemia Major child with Evans Syndrome

GAIMS Journal of Medical Sciences, 2023
Patients with β-Thalassemia Major are at risk of alloimmunization and autoimmunization because they need regular multiple blood transfusions. Here we are reporting a case of an 8 years old male child, known case of β-thalassemia major, who developed ...
Rekha Thaddanee, Ekta Thacker, Shamim Morbiwala, Vinisha Makhijani, Bhushan M Warpe, Vishva Sureja   +5 more
doaj   +1 more source

Evans Syndrome

Journal of Medicine, 1970
Evans' syndrome is a rare autoimmune disorder in which the body makes antibodies that destroy the red blood cells, platelets and white blood cells. Patients are diagnosed with thrombocytopenia and Coombs' positive haemolytic anaemia and have no other known underlying aetiology. We report two cases of autoimmune haemolytic anaemia (AIHA) associated with
Ahmedul Kabir, Jayanta Banik, Ratan Das Gupta, Md Robed Amin, AM Wasiq Faisal, ASM Mafidul Islam, Mostofa Kamal, Pinaki Paul, Farzana Chowdhury, Hasna Hena Parveen   +9 more
openaire   +2 more sources

Are there “Attenuated” Forms of Evans Syndrome? [PDF]

Hematology, 2001
Indirect evidence of hemolysis has been described in patients with autoimmune thrombocytopenic purpura. In order to collect more data, another method to assess red blood cell destruction in these patients was employed: measurement of free haptoglobin levels. In 17 individuals with autoimmune thrombocytopenic purpura the levels of free haptoglobins were
G J, Ruiz-Argüelles, B, López-Martínez, E, Estrada, G J, Ruiz-Delgado, D, Alarcón-Segovia   +4 more
openaire   +2 more sources

Determining the timeline of gonadal and genital differentiation in male and female equine fetuses allows for early detection and intervention in malformations

The Anatomical Record, EarlyView.
Abstract Sexual differentiation in the equine fetus involves coordinated morphogenetic processes that shape both the gonads and the genital ducts. Although the formation of testes and ovaries has been relatively well documented, the temporal dynamics and morphometric patterns of the mesonephric (Wolffian) and paramesonephric (Müllerian) ducts remain ...
Tais Harumi de Castro Sasahara, Silvio Pires Gomes, Fabio Cesar Magioli Abdala, Bruno Cesar Schimming, Maria Angelica Miglino   +4 more
wiley   +1 more source

A Factor‐Analytic Approach for Psychometric Properties of the Repetitive Behaviors Questionnaire‐3 (RBQ‐3) for Turkish Population

Autism Research, EarlyView.
ABSTRACT Restricted and repetitive behaviors (RRBs) are one of the diagnostic criteria for autism spectrum disorders (ASD), as well as being found in the general population. The current study aims to explore the psychometric properties of the Turkish self‐report and informant‐report forms of the Repetitive Behaviors Questionnaire‐3 (RBQ‐3) for ...
Volkan Avşar, Hatice Şengül Erdem, Asiye Şengül Avşar   +2 more
wiley   +1 more source