Results 131 to 140 of about 305,125 (284)
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
La universidad en la cultura tributaria. The university at tax culture
Retos, 2012 Hoy Ecuador tiene que ir camino hacia la adopción de una cultura tributaria, es necesario insistir en el intento de la concientización, más aún cuando de por medio se encuentra nuestra idiosincrasia, no tanto como un desmedro de nuestra autoestima sino ...
Jorge Quintanilla Gavilánez
doaj +1 more source
Tax Rates, Tax Evasion, and Growth in a Multi-period Economy [PDF]
We extend the basic tax evasion model to a multi-period economy exhibiting sustained growth. When individuals conceal part of their true income from the tax authority, they face the risk of being audited and hence of paying the corresponding fine.
Jordi Caballé, Judith Panadés
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley +12 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou +11 more
wiley +1 more source
Mujeres en la universidad_pública en Brasil-Caso UNILA_ Acceso y permanencia de las estudiantas desde una perspectiva de_género y latinoamericanista [PDF]
, 2019 Informe final correspondiente a la investigación dentro del marco de los Estudos da Unila- Edito N° 6 IMEA.IMEA ...
Angélica, Alvarado, Juliana, Vargas
core
Advanced Functional Materials, EarlyView.A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu +8 more
wiley +1 more source
1985: las fuentes de ingresos del gobierno mexicano [PDF]
, 1984 El mecanismo para aumentar los ingresos del estado mexicano, según se afirma en la Exposición de motivos de la Ley de Ingresos para 1985, es a través de un ataque a la evasión y elusión fiscales, así como de mejoras en materia tributaria; pero, ¿se dan ...
Astudillo Moya, Marcela
core
Advanced Functional Materials, EarlyView.A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo +7 more
wiley +1 more source