Results 161 to 170 of about 250,617 (285)

Targeting the chemokine-Treg axes in tumor immune evasion: from mechanisms to therapeutic opportunities. [PDF]

Front Immunol
Lian C, Liu L, Zhang X.
europepmc   +1 more source

Implicancias de la elusión y evasión tributaria en la recaudación de impuestos de la Amazonia Peruana

Universidad de Huánuco, Luis Huaytan Tucto, Miker Cupe Chalco, Universidad Nacional Mayor de San Marcos   +3 more
openalex   +1 more source

Instrumento de pesquisa para prevenção da evasão nas instituições de ensino superior à distância: metodologia de construção = Instrument of research for evasion prevent ion at distance higher education institutions: construction methodology = Instrumento de investigación para prevención de la evasión en las instituciones de enseñanza superior a distancia: metodología de construcción

, 2021
Oberdan Santos da Costa
openalex   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Immune evasion, dysregulation, and emerging immunotherapies for invasive fungal infections in the immunocompromised host. [PDF]

Front Immunol
Liu H, Wang C, Huang W, Hu S, Huang C.
europepmc   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

How White people manage the weight of the past: The role of advantaged identity strategies in linking colonialism to current racial inequality. [PDF]

Br J Soc Psychol
Cáceres Quezada E, Kende J, Boiger M, Hickson H, Hitschfel C, Doosje B.   +5 more
europepmc   +1 more source

El nuevo convenio multilateral: un paso a delante de la OCDE en la armonización fiscal en contra de la evasión y la elusión fiscal

, 2018
Pedro Jesús Jiménez Vargas
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source