Results 261 to 270 of about 305,125 (284)

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

IRAK4 Regulates NF-κB signaling to suppress CD8 + T cell activity and promote immune evasion in glioblastoma development. [PDF]

Cancer Immunol Immunother
Xue Z, Song Z, Mo L, Shi L, Yang S.
europepmc   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

deltaHED predicts survival and immune evasion in PD-1 blockade therapy: A multi-cohort study across three cancer types. [PDF]

Clin Transl Med
Xu J, Wei X, Yao J, Mahajan UM, Kahlert UD, Shi R, Zhang K, Alnatsha A, Qian Z, Han F, Wang F.   +10 more
europepmc   +1 more source

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

Hyperglycemia drives lmmune evasion in colorectal cancer through VISTA stabilization. [PDF]

Cell Commun Signal
Liu X, Liu Q, Guo D, Zhao Z, Wang J, Xiang Y, Wang K, Yang L, Zhu K, Wang L, Li R, Gao X, Zhang C, Cheng Y, Yan D, Tong Y.   +15 more
europepmc   +1 more source

Epstein-Barr virus functional RNAs as part of its immune evasion strategy: a role for EBER1? [PDF]

Open Biol
Farrell PJ.
europepmc   +1 more source

Immune Delay, Beyond Immune Evasion, as a Driver of Pathogen Propagation Competence Through Neutrophil Dysregulation, to be Mitigated by Low-Frequency Electromagnetic Fields (LF-EMF). [PDF]

Int J Mol Sci
Cuppen JJM, Savelkoul HFJ.
europepmc   +1 more source

The influence of ferroptosis-associated gene HSPA5 on the prognosis and immune evasion of lung adenocarcinoma. [PDF]

Discov Oncol
Xiong L, Gao X, Wang L, Luo L, Su J, Wang Y, Shen Y.   +6 more
europepmc   +1 more source

USP18 promote tumor immune evasion in pancreatic cancer through enhancing autolysosome-mediated degradation of MHC-I. [PDF]

Am J Cancer Res
Fang Y, Wang J, Fu B, Yu Y, Mao Q, Yao M, Yu X, Cai J.   +7 more
europepmc   +1 more source