Results 41 to 50 of about 4,435 (261)

Reforma tributaria y evasión fiscal en Colombia, 2018 - 2021 [PDF]

, 2022
El proyecto de investigación denominado Reforma tributaria y evasión fiscal en Colombia, 2018- 2021, en un trabajo enfocado en identificar las medidas de política pública tomadas por el gobierno nacional, encabeza del presidente Iván Duque M.; con el ...
Arenas Niño, Silvia Viviana
core  

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Evasión de impuestos: un enigma en la sociedad colombiana

Episteme, 2021
En este escrito se pretende ilustrar de manera general y concisa cómo la evasión de los impuestos genera subdesarrollo y atraso en la sociedad colombiana, teniendo en cuenta que a través del tiempo las diferentes normas y leyes que los rigen benefician ...
Arístides de Jesús Díaz González
doaj   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Dimensions of Causal Attributions of Tax Evasion in Portugal

Journal of Work and Organizational Psychology, 2010
Un estudio realizado en España (Salgado, 1998) sugirió que las atribuciones de la evasión fiscal tienen dos dimensiones independientes: (a) control de la evasión fiscal, y (b) las creencias sobre el sistema fiscal.
José C. Tavares, Mar Iglesias
doaj  

Money laundering, embezzlement and tax evasion: a teaching case

Revista Ambiente Contábil
Purpose: This teaching case aims to deepen the knowledge related to money laundering, misappropriation and tax evasion, to encourage the debate in classroom on the accountant's responsibility and ethical dilemma when faced with evidence that their ...
Rodrigo de Souza Gonçalves, Patricia Garone Figueira Falcão, Monick Rodrigues Lima   +2 more
doaj   +1 more source

Factores que causan la evasión fiscal en el Ecuador [PDF]

, 2021
La evasión o fraude fiscal ha sido considerada como una figura jurídica intencionada o conducta ilícita por parte de sujetos pasivos que generan actividades gravadas en el país, por tanto, es necesario conocer cuáles son los factores que originan una ...
Rivera Suárez, Verónica Jazmín
core  

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source