Results 151 to 160 of about 1,173,800 (295)
Annals of Neurology, EarlyView.We used targeted immunopurification‐mass spectrometry (IP‐MS) to characterize human neurofilament light chain (NfL) proteoforms across various compartments to assess their alterations in amyotrophic lateral sclerosis (ALS). NfL is truncated in cerebrospinal fluid (CSF) and blood in patients with sporadic ALS (sALS) and these proteoforms differ between ...
John B. Coulton +11 more
wiley +1 more source
Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort
Annals of Neurology, EarlyView.Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov +42 more
wiley +1 more source
OntoSecAI: Ontology-driven security automation for AI-enabled systems. [PDF]
PLoS OneUllah U, Haleem M, Ullah A.
europepmc +1 more source
Micro/Nanorobot for Drug Delivery—A Review of Material Selections
Advanced NanoBiomed Research, EarlyView.This review explores material strategies for biomedical micro/nanorobots, emphasizing their roles in propulsion, navigation, drug delivery, and biodegradability. It highlights advancements in metallic, polymeric, and hybrid materials, while addressing clinical translation challenges such as toxicity, immune response, and manufacturability.
Xiaozhuo Wu, Bingyun Li, Malcolm Xing
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
Security of ADS-B and Remote ID Systems: Cyberattacks, Detection Techniques, and Countermeasures. [PDF]
Sensors (Basel)Shi Q, Caleb TD, Shao S, Kaabouch N.
europepmc +1 more source
Angewandte Chemie International Edition, EarlyView.The structure of the non‐canonical C16 sesquiterpene named hegelenether was revised to the structure of marxdiol, and its absolute configuration was assigned. Isotopic labeling experiments revealed the stereochemical course of the methyltransferase involved in its biosynthesis.
Heng Li +3 more
wiley +1 more source
Hypoimmune stem cells and islets: hype or a true breakthrough in diabetes treatment? [PDF]
Cell Mol Biol LettShalaby KE, Abdelalim EM.
europepmc +1 more source
Prioritizing Feasible and Impactful Actions to Enable Secure AI Development and Use in Biology
Biotechnology and Bioengineering, EarlyView.ABSTRACT As artificial intelligence continues to enhance biological innovation, the potential for misuse must be addressed to fully unlock the potential societal benefits. While significant work has been done to evaluate general‐purpose AI and specialized biological design tools (BDTs) for biothreat creation risks, actionable steps to mitigate the risk
Josh Dettman +4 more
wiley +1 more source
Toward cancer immunoprevention: what are the prospects for therapeutic vaccines? [PDF]
Ann Med Surg (Lond)Tague C +8 more
europepmc +1 more source