Results 91 to 100 of about 3,052,896 (261)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

On Sidon sequences of even orders [PDF]

open access: yesActa Arithmetica, 1993
Let \(h\geq 2\) be an integer. A set of positive integers \(A\) is called a \(B_ h\)-sequence, or a Sidon sequence of order \(h\), if all sums \(a_ 1+a_ 2+ \cdots+a_ h\), where \(a_ i\in B\) (\(i=1,2,\dots,h\)), are distinct up to rearrangements of the summands. Let \(A(n)\) be the cardinality of the set \(A\cap [0,n]\). It is proved that, for any \(B_{
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Lower and Upper Solutions for Even Order Boundary Value Problems

open access: yesMathematics, 2019
In this paper, we prove the existence of solutions of nonlinear boundary value problems of arbitrary even order using the lower and upper solutions method.
Alberto Cabada, Lucía López-Somoza
doaj   +1 more source

Cyclic affine planes of even order

open access: yesDiscrete Mathematics, 1989
Let a be an integer. If t is any integer with \((t,a)=1\), \(\exp_ a(t)\) would mean the smallest positive integer \(\ell\) such that \(t^{\ell}\equiv 1 (mod a)\). Let (p/q) be the Legendre symbol. The main purpose of the paper is to prove the following result. Suppose that there exists a cyclic affine plane of even order n. Then (1) either \(n=2\) or \
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Oscillatory criteria of noncanonical even-order differential equations with a superlinear neutral term

open access: yesBoundary Value Problems
The oscillatory behavior of solutions of an even-order differential equation with a superlinear neutral term is considered using Riccati and generalized Riccati transformations, the integral averaging technique, and the theory of comparison.
A. A. El-Gaber
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy