Results 181 to 190 of about 312,730 (296)

Interactive effects of sleep duration and morning/evening preference on cardiovascular risk factors

European Journal of Public Health, 2018
F. Patterson, S. Malone, M. Grandner, Alicia J Lozano, M. Perkett, A. Hanlon   +5 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cross-Sectional Analysis of Sleep Quality and Vascular Health in Shift- and Day-Working Nurses. [PDF]

Clocks Sleep
Saharov G, Salti B, Bareya M, Keren-Politansky A, Nadir Y, Shochat T.   +5 more
europepmc   +1 more source

Are Evening Surgeries Necessary? [PDF]

, 1964
Chris Roberts
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evening home pulse pressure predicted cardiovascular events and mortality in older adults with hypertension: findings based on the STEP trial. [PDF]

Hypertens Res
Ji Y, Peng X, Chen S, Song Q, Bai J, Cai J.   +5 more
europepmc   +1 more source

Weight Loss is Greater with Consumption of Large Morning Meals and Fat-Free Mass Is Preserved with Large Evening Meals in Women on a Controlled Weight Reduction Regimen , [PDF]

, 1997
Nancy L. Keim, Marta D. Van Loan, William Horn, Teresa Barbieri, P Mayclin   +4 more
openalex   +1 more source

Understanding sleep-wake behavior in late chronotype adolescents: The role of circadian phase, sleep timing, and evening vigilance

, 2021
Christin Lang, Cele Richardson, Gorica Micic, Michael Gradisar   +3 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Two Cases of Severe Insulin Resistance in Pregnancy: A New Diagnosis of <i>INSR</i> Variant and a Patient with SHORT Syndrome. [PDF]

JCEM Case Rep
L'Amie AK, Hall RM, Bate J, Cox S, Murphy R.   +4 more
europepmc   +1 more source