Results 111 to 120 of about 107,823 (286)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Composition and diversity of woody plant species in agro-ecosystems of Uluguru Mountains, Tanzania

open access: yesForest Science and Technology
Woody plant species are important components of agro-ecosystems that determine their productivity and biodiversity conservation in tropical mountain landscapes.
Lisa Mbaruku   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Estrutura do fitoplâncton, em curto período de tempo, em um braço do reservatório de Rosana (ribeirão do Corvo, Paraná, Brasil) = Short-term changes in phytoplankton structure in an arm of the Rosana reservoir, Paraná-São Paulo States, Brazil

open access: yesActa Scientiarum: Biological Sciences, 2008
Com o objetivo de analisar as mudanças de curta duração da comunidadefitoplanctônica, em um braço do reservatório de Rosana, formado pelo ribeirão do Corvo, foram coletadas amostras de fitoplâncton total em tréplicas à subsuperfície da região pelágica. O
Paula Aparecida Federiche Borges   +1 more
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Comparison of measures of crowding, group size, and diversity

open access: yesEcosphere, 2017
In ecology, diversity is often measured as the mean rarity of species in a community. In behavioral sciences and parasitology, mean crowding is the size of the group to which a typical individual belongs.
Zsolt Lang   +2 more
doaj   +1 more source

Small Extended Formulations for Cyclic Polytopes

open access: yes, 2015
We provide an extended formulation of size O(log n)^{\lfloor d/2 \rfloor} for the cyclic polytope with dimension d and n vertices (i,i^2,\ldots,i^d), i in [n]. First, we find an extended formulation of size log(n) for d= 2. Then, we use this as base case
Bogomolov, Yuri   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

On the diversity‐based measures of equalness and evenness

open access: yesMethods in Ecology and Evolution
While the notion of evenness is generally undisputed, its opposite, unevenness, is vague. Conventionally, evenness is understood to decrease, and thus unevenness to increase, as the effective number of types of positive frequency tends towards one while ...
Hans‐Rolf Gregorius   +1 more
doaj   +1 more source

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