Results 141 to 150 of about 41,806 (268)

Effect of selenium hyperaccumulation on the root endophytic and rhizosphere microbiome of two Astragalus species. [PDF]

Plant Biol (Stuttg)
Dotson C, Kurowski C, Grillo M.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Spring Zooplankton Community Structure and Its Relationship with Water Quality Gradients in Representative Nearshore Systems of the Beibu Gulf, China. [PDF]

Animals (Basel)
Wang S, Xu M, Zeng J, Xu W, Li Z, Li S, Tai VC.   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assessing Biodiversity in Agricultural Landscapes Through Drone-Based Environmental DNA Sampling. [PDF]

Ecol Evol
Albouy C, Humbert L, Niedermeier K, Chautem M, Fopp F, Luthi M, Thurnheer S, Marques V, Kirchgeorg S, Geckeler C, Nasrallah A, Mintchev S, Pellissier L.   +12 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Haemophilus abundance is associated with response to sublingual immunotherapy in children with allergic rhinitis. [PDF]

Pediatr Allergy Immunol
Teng ZP, Han QQ, Shen XF.
europepmc   +1 more source

Patterns in Alpha Spectra of Even-Even Nuclei [PDF]

Physical Review, 1953
Asaro, Frank, Perlman, I.
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Salas y Gomez and Nazca Ridges EBSA support a highly functional diversity of seabirds. [PDF]

Sci Rep
Núñez P, Luna-Jorquera G.
europepmc   +1 more source