Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Tissue and peripheral T cell receptor repertoire predicts immunotherapy response and progression-free survival in NSCLC patients. [PDF]
Sci RepPino-González M +8 more
europepmc +1 more source
Dynamics of the immune repertoire in recurrent, locally advanced NSCLC not amenable for definitive therapy and in stage IV disease receiving first-line chemotherapy. [PDF]
Front OncolTrachu N +13 more
europepmc +1 more source
Environmental change shapes understory plant diversity and dominance in boreal forests. [PDF]
Nat CommunChen X +6 more
europepmc +1 more source
Trade-offs in cotton pest management: Seed treatments suppress pests but reduce the abundance of natural enemies in the arthropod community. [PDF]
PLoS OneYalçin M.
europepmc +1 more source
Soil pH mediates the impact of pesticides on bacterial communities, diversity, and abundance. [PDF]
Front MicrobiolNémethová E +4 more
europepmc +1 more source
Bacterial communities associated with the blue dragon nudibranch <i>Glaucilla marginata</i> from Phuket, Thailand. [PDF]
PeerJPhongphattarawat S, Songvorawit N.
europepmc +1 more source