Results 201 to 210 of about 107,594 (348)

Stool Dynamics and the Developing Gut Microbiome During Infancy. [PDF]

open access: yesJ Biol Rhythms
Al-Andoli M   +9 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Towards Key Principles of Host-Associated Microbiome Assembly. [PDF]

open access: yesEcol Lett
Araujo G   +4 more
europepmc   +1 more source

Even Cooler?! [PDF]

open access: yesCirculation: Arrhythmia and Electrophysiology, 2013
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

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