Results 181 to 190 of about 107,594 (348)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Soil phosphorus availability drives decade-scale stability across life stages in a subtropical forest. [PDF]

Sci Adv
Feng G, Dai D, Zheng Y, Johnson D, Burslem DFRP, Yu S, Liu X, Liang M.   +7 more
europepmc   +1 more source

Is indeterminacy even possible?

, 2023
Graham Little
openalex   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effect of Nutrient Enrichment on Alpha and Beta Diversity of Macroinvertebrate Community in a Boreal River of Northern China. [PDF]

Biology (Basel)
Sun X, Guo Y, Wang X, Li W, Li C, Lou Y, Cao S, Wang Z, Li Z, Liu G.   +9 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Fenced enclosure and increased rainfall facilitate recovery of degraded desert steppe by restructuring soil seed bank dynamics. [PDF]

BMC Plant Biol
Chen H, Fan G, Baskin CC, Baskin JM, Cui Q, Liu H, Huang Z.   +6 more
europepmc   +1 more source

A Clinical Case of Pulmonary Tuberculosis: Complete Recovery Following Pneumothorax Treatment Even in a Case with Cavitation.

, 1935
Nadig Nr
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

First record of Lutzomyia cruzi and phlebotomine sand fly diversity in a rural settlement of the metropolitan area in Central-west Brazil. [PDF]

Rev Bras Parasitol Vet
Macanham DC, Moura JM, Menegatti JA, Souza CO, Dias ÁFLR.   +4 more
europepmc   +1 more source