Results 171 to 180 of about 107,594 (348)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Multiple Community Properties Drive Ecosystem Resistance and Resilience to Extreme Climate Events Across Mesic Grasslands. [PDF]

open access: yesEcol Lett
Ajowele JA   +14 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Uncertainty of the pavement evenness assessment

open access: yes, 2013
Równość nawierzchni drogowej jest cechą eksploatacyjną, którą bezpośrednio odczuwają jej użytkownicy. W artykule omówiono możliwe przyczyny rozbieżności ocen równości nawierzchni w aspekcie niepewności metody pomiarowej.
Szpinek, S.
core  

Influences of Structural and Species Diversity on Forest Resistance to Drought. [PDF]

open access: yesEcol Lett
Crockett ETH   +11 more
europepmc   +1 more source

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