Results 231 to 240 of about 107,823 (286)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Size- and Time-Dependent Effects of Polyethylene Microplastics on Soil Nematode Communities: A 360-Day Field Experiment. [PDF]

Toxics
He T, Zhu S, Liu X, Chen J, He L, Wang K, Zhu Y, Xu H.   +7 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Biofilm communities above and below the cuff of endotracheal tubes are spatially homogenous. [PDF]

Respir Res
Einarsson GG, Das S, Silversides JA, Fundano N, Lonsdale E, McMullan R, McAuley DF, Irwin NJ, McCoy CP, Wylie MP, Sherrard LJ.   +10 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Paired Duodenal and Salivary Microbiome Analysis in Pancreatic Cancer Without Duct Obstruction. [PDF]

United European Gastroenterol J
Archibugi L, Bertoldi L, Benvenuto G, Sattin E, Ponz De Leon Pisani R, Fortunato C, Mariani A, Rossi G, Petrone MC, Valle G, Reni M, Falconi M, Arcidiacono PG, Capurso G.   +13 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Influence of different industrial resource profiles on taxonomical richness and community structure of insects populations. [PDF]

Sci Rep
Shahat MAM, El-Tabakh MAM, Hamza YI, Elnaggar AMA, Ward WMA, Abd-Elkhalek HF, Shehata AZI.   +6 more
europepmc   +1 more source

STRUCTURE OF EVEN-EVEN AND EVEN-ODD XE NUCLIDES

, 2016
Mantica, P, Carter, H, Zimmerman, B, Walters, W, Rikovska, J, Stone, N, Rupnik, D, Zganjar, E   +7 more
openaire   +1 more source