Results 171 to 180 of about 508 (225)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

About optimum signalling of information [PDF]

, 1989
Vajda, Igor
core  

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Maximalization on Event Types

Studies in Linguistics and Philosophy, 2000
In this lecture, I will propose an analysis of cumulative readings involving non-upward entailing noun phrases. I will do this by addressing the more general problem of how to deal with non-upward entailing information in the Davidsonian theory.
exaly   +2 more sources

Maximizing the Probability of k-Covering an Event Location

2020 IEEE 16th International Conference on Control & Automation (ICCA), 2020
In various sensor network applications like monitoring and target localization, the occurrence of an event can only be effectively located if it falls within the sensing range of at least k ≥ 3 sensors. In this paper, we develop an algorithm to optimize to optimize the positions and orientations of heterogeneous sensors in order to maximize the ...
Chaohui Gong, Chujun Gong, Zhong Guo, Yanwei Zang, Weilin Wang   +4 more
openaire   +1 more source

Maximizing lifetime of event-unobservable wireless sensor networks

Computer Standards & Interfaces, 2011
In wireless sensor networks (WSNs) contextual information such as the information regarding whether, when, and where the data is collected cannot be protected using only traditional measures (e.g., encryption). Contextual information can be protected against global eavesdroppers by periodic packet transmission combined with dummy traffic filtering at ...
Kemal Bicakci, Hakan Gultekin, Bülent Tavli, Ibrahim Ethem Bagci   +3 more
openaire   +2 more sources

Mining Maximal Co-located Event Sets

2011
A spatial co-location is a set of spatial events being frequently observed together in nearby geographic space. A common framework for mining spatial association patterns employs a level-wised search method (like Apriori). However, the Apriori-based algorithms do not scale well for discovering long co-location patterns in large or dense spatial ...
Jin Soung Yoo, Mark Bow
openaire   +1 more source

The maximal steady state versus selected running events

Medicine and Science in Sports and Exercise, 1981
To investigate the relationship between the maximal steady state (MSS) and selected running events, seven males (mean = 37.6 years) who were experienced competitive distance runners were studied. From a series of 10-min steady-state treadmill runs, MSS (treadmill velocity, VO2, or heart rate where lactic acid concentration was 2.2 mM/L of venous blood)
T P, LaFontaine, B R, Londeree, W K, Spath   +2 more
openaire   +2 more sources

Event Cameras, Contrast Maximization and Reward Functions: An Analysis

2019 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2019
Event cameras asynchronously report timestamped changes in pixel intensity and offer advantages over conventional raster scan cameras in terms of low-latency, low redundancy sensing and high dynamic range. In recent years, much of research in event based vision has been focused on performing tasks such as optic flow estimation, moving object ...
Timo Stoffregen, Lindsay Kleeman
openaire   +1 more source