Results 51 to 60 of about 1,416,187 (309)

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Machine Learning Approach for Event Position Reconstruction in the DEAP-3600 Dark Matter Search Experiment

Physics, 2023
In addition to classical analytical data processing methods, machine learning methods are widely used for data analysis in elementary particle physics.
DEAP Collaboration
doaj   +1 more source

Measurement of the underlying event in jet events from 7 TeV proton-proton collisions with the ATLAS detector [PDF]

Eur.Phys.J.C74 (2014) 2965, 2014
Distributions sensitive to the underlying event in QCD jet events have been measured with the ATLAS detector at the LHC, based on 37/pb of proton-proton collision data collected at a centre-of-mass energy of 7 TeV. Charged-particle mean $p_T$ and densities of all-particle $E_T$ and charged-particle multiplicity and $p_T$ have been measured in regions ...
arxiv   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

FEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source

Event generators for high-energy physics experiments

SciPost Physics
We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements.
J. M. Campbell, M. Diefenthaler, T. J. Hobbs, S. Höche, J. Isaacson, F. Kling, S. Mrenna, J. Reuter, S. Alioli, J. R. Andersen, C. Andreopoulos, A. M. Ankowski, E. C. Aschenauer, A. Ashkenazi, M. D. Baker, J. L. Barrow, M. van Beekveld, G. Bewick, S. Bhattacharya, C. Bierlich, E. Bothmann, P. Bredt, A. Broggio, A. Buckley, A. Butter, J. M. Butterworth, E. P. Byrne, C. M. Carloni-Calame, S. Chakraborty, X. Chen, M. Chiesa, J. T. Childers, J. Cruz-Martinez, J. Currie, N. Darvishi, M. Dasgupta, A. Denner, F. A. Dreyer, S. Dytman, B. K. El-Menoufi, T. Engel, S. Ferrario Ravasio, D. Figueroa, L. Flower, J. R. Forshaw, R. Frederix, A. Friedland, S. Frixione, H. Gallagher, K. Gallmeister, S. Gardiner, R. Gauld, J. Gaunt, A. Gavardi, T. Gehrmann, A. Gehrmann-De Ridder, L. Gellersen, W. Giele, S. Gieseke, F. Giuli, E. W. N. Glover, M. Grazzini, A. Grohsjean, C. Gütschow, K. Hamilton, T. Han, R. Hatcher, G. Heinrich, I. Helenius, O. Hen, V. Hirschi, M. Höfer, J. Holguin, A. Huss, P. Ilten, S. Jadach, A. Jentsch, S. P. Jones, W. Ju, S. Kallweit, A. Karlberg, T. Katori, M. Kerner, W. Kilian, M. M. Kirchgaeßer, S. Klein, M. Knobbe, C. Krause, F. Krauss, J. Lang, J. -N. Lang, G. Lee, S. W. Li, M. A. Lim, J. M. Lindert, D. Lombardi, L. Lönnblad, M. Löschner, N. Lurkin, Y. Ma, P. Machado, V. Magerya, A. Maier, I. Majer, F. Maltoni, M. Marcoli, G. Marinelli, M. R. Masouminia, P. Mastrolia, O. Mattelaer, J. Mazzitelli, J. McFayden, R. Medves, P. Meinzinger, J. Mo, P. F. Monni, G. Montagna, T. Morgan, U. Mosel, B. Nachman, P. Nadolsky, R. Nagar, Z. Nagy, D. Napoletano, P. Nason, T. Neumann, L. J. Nevay, O. Nicrosini, J. Niehues, K. Niewczas, T. Ohl, G. Ossola, V. Pandey, A. Papadopoulou, A. Papaefstathiou, G. Paz, M. Pellen, G. Pelliccioli, T. Peraro, F. Piccinini, L. Pickering, J. Pires, W. Placzek, S. Plätzer, T. Plehn, S. Pozzorini, S. Prestel, C. T. Preuss, A. C. Price, S. Quackenbush, E. Re, D. Reichelt, L. Reina, C. Reuschle, P. Richardson, M. Rocco, N. Rocco, M. Roda, A. Rodriguez Garcia, S. Roiser, J. Rojo, L. Rottoli, G. P. Salam, M. Schönherr, S. Schuchmann, S. Schumann, R. Schürmann, L. Scyboz, M. H. Seymour, F. Siegert, A. Signer, G. Singh Chahal, A. Siódmok, T. Sjöstrand, P. Skands, J. M. Smillie, J. T. Sobczyk, D. Soldin, D. E. Soper, A. Soto-Ontoso, G. Soyez, G. Stagnitto, J. Tena-Vidal, O. Tomalak, F. Tramontano, S. Trojanowski, Z. Tu, S. Uccirati, T. Ullrich, Y. Ulrich, M. Utheim, A. Valassi, A. Verbytskyi, R. Verheyen, M. Wagman, D. Walker, B. R. Webber, L. Weinstein, O. White, J. Whitehead, M. Wiesemann, C. Wilkinson, C. Williams, R. Winterhalder, C. Wret, K. Xie, T-Z. Yang, E. Yazgan, G. Zanderighi, S. Zanoli, K. Zapp
doaj   +1 more source

Modelling of a double‐scattering proton therapy nozzle using the FLUKA Monte Carlo code and analysis of linear energy transfer in patients treated for prostate cancer

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The dose‐averaged linear energy transfer (LETD) in proton therapy (PT) has in pre‐clinical studies been linked to the relative biological effectiveness (RBE) of protons. Until recently, the most common PT delivery method in prostate cancer has been double‐scattered PT, with LETD only available through dedicated Monte Carlo (MC ...
Rasmus Klitgaard, Lars Fredrik Fjæra, Camilla Hanquist Stokkevåg, Perry Johnson, Mark Artz, Nancy Price Mendenhall, Curtis Bryant, Ludvig Paul Muren   +7 more
wiley   +1 more source

Requirements on common solutions to the LSND and MiniBooNE excesses: a post-MicroBooNE study

Journal of High Energy Physics, 2022
The strong statistical significance of an observed electron-like event excess in the MiniBooNE (MB) experiment, along with an earlier similar excess seen in the Liquid Scintillator Neutrino Detector (LSND), when interpreted in conjunction with recent ...
Waleed Abdallah, Raj Gandhi, Samiran Roy
doaj   +1 more source

Evaluation of the effect of metal stents on dose perturbation in the carbon beam irradiation field

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Propose Carbon ion therapy is indicated for cases in which stents have been inserted, such as bile ducts, but the effect of metal stents on carbon ion therapy is unclear. In this study, the dose perturbation of carbon ion therapy caused by metallic bile duct stents was evaluated by dosimetry. Materials and methods Five different types of metal
Yuya Miyasaka, Tetsuya Ishizawa, Yoshihito Nawa, Hikaru Souda, Shohei Kawashiro, Hongbo Chai, Miyu Ishizawa, Hiraku Sato, Takeo Iwai   +8 more
wiley   +1 more source