Results 41 to 50 of about 17,184 (253)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Scintillation in Low-Temperature Particle Detectors

Physics, 2021
Inorganic crystal scintillators play a crucial role in particle detection for various applications in fundamental physics and applied science. The use of such materials as scintillating bolometers, which operate at temperatures as low as 10 mK and detect
Denys Poda
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Event generators for high-energy physics experiments

SciPost Physics
We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements.
J. M. Campbell, M. Diefenthaler, T. J. Hobbs, S. Höche, J. Isaacson, F. Kling, S. Mrenna, J. Reuter, S. Alioli, J. R. Andersen, C. Andreopoulos, A. M. Ankowski, E. C. Aschenauer, A. Ashkenazi, M. D. Baker, J. L. Barrow, M. van Beekveld, G. Bewick, S. Bhattacharya, C. Bierlich, E. Bothmann, P. Bredt, A. Broggio, A. Buckley, A. Butter, J. M. Butterworth, E. P. Byrne, C. M. Carloni-Calame, S. Chakraborty, X. Chen, M. Chiesa, J. T. Childers, J. Cruz-Martinez, J. Currie, N. Darvishi, M. Dasgupta, A. Denner, F. A. Dreyer, S. Dytman, B. K. El-Menoufi, T. Engel, S. Ferrario Ravasio, D. Figueroa, L. Flower, J. R. Forshaw, R. Frederix, A. Friedland, S. Frixione, H. Gallagher, K. Gallmeister, S. Gardiner, R. Gauld, J. Gaunt, A. Gavardi, T. Gehrmann, A. Gehrmann-De Ridder, L. Gellersen, W. Giele, S. Gieseke, F. Giuli, E. W. N. Glover, M. Grazzini, A. Grohsjean, C. Gütschow, K. Hamilton, T. Han, R. Hatcher, G. Heinrich, I. Helenius, O. Hen, V. Hirschi, M. Höfer, J. Holguin, A. Huss, P. Ilten, S. Jadach, A. Jentsch, S. P. Jones, W. Ju, S. Kallweit, A. Karlberg, T. Katori, M. Kerner, W. Kilian, M. M. Kirchgaeßer, S. Klein, M. Knobbe, C. Krause, F. Krauss, J. Lang, J. -N. Lang, G. Lee, S. W. Li, M. A. Lim, J. M. Lindert, D. Lombardi, L. Lönnblad, M. Löschner, N. Lurkin, Y. Ma, P. Machado, V. Magerya, A. Maier, I. Majer, F. Maltoni, M. Marcoli, G. Marinelli, M. R. Masouminia, P. Mastrolia, O. Mattelaer, J. Mazzitelli, J. McFayden, R. Medves, P. Meinzinger, J. Mo, P. F. Monni, G. Montagna, T. Morgan, U. Mosel, B. Nachman, P. Nadolsky, R. Nagar, Z. Nagy, D. Napoletano, P. Nason, T. Neumann, L. J. Nevay, O. Nicrosini, J. Niehues, K. Niewczas, T. Ohl, G. Ossola, V. Pandey, A. Papadopoulou, A. Papaefstathiou, G. Paz, M. Pellen, G. Pelliccioli, T. Peraro, F. Piccinini, L. Pickering, J. Pires, W. Placzek, S. Plätzer, T. Plehn, S. Pozzorini, S. Prestel, C. T. Preuss, A. C. Price, S. Quackenbush, E. Re, D. Reichelt, L. Reina, C. Reuschle, P. Richardson, M. Rocco, N. Rocco, M. Roda, A. Rodriguez Garcia, S. Roiser, J. Rojo, L. Rottoli, G. P. Salam, M. Schönherr, S. Schuchmann, S. Schumann, R. Schürmann, L. Scyboz, M. H. Seymour, F. Siegert, A. Signer, G. Singh Chahal, A. Siódmok, T. Sjöstrand, P. Skands, J. M. Smillie, J. T. Sobczyk, D. Soldin, D. E. Soper, A. Soto-Ontoso, G. Soyez, G. Stagnitto, J. Tena-Vidal, O. Tomalak, F. Tramontano, S. Trojanowski, Z. Tu, S. Uccirati, T. Ullrich, Y. Ulrich, M. Utheim, A. Valassi, A. Verbytskyi, R. Verheyen, M. Wagman, D. Walker, B. R. Webber, L. Weinstein, O. White, J. Whitehead, M. Wiesemann, C. Wilkinson, C. Williams, R. Winterhalder, C. Wret, K. Xie, T-Z. Yang, E. Yazgan, G. Zanderighi, S. Zanoli, K. Zapp
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Machine Learning Approach for Event Position Reconstruction in the DEAP-3600 Dark Matter Search Experiment

Physics, 2023
In addition to classical analytical data processing methods, machine learning methods are widely used for data analysis in elementary particle physics.
DEAP Collaboration
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A likelihood framework for cryogenic scintillating calorimeters used in the CRESST dark matter search

European Physical Journal C: Particles and Fields
Cryogenic scintillating calorimeters are ultra- sensitive particle detectors for rare event searches, particularly for the search for dark matter and the measurement of neutrino properties.
CRESST Collaboration, G. Angloher, S. Banik, G. Benato, A. Bento, A. Bertolini, R. Breier, C. Bucci, J. Burkhart, L. Canonica, A. D’Addabbo, S. Di Lorenzo, L. Einfalt, A. Erb, F. v. Feilitzsch, S. Fichtinger, D. Fuchs, A. Garai, V. M. Ghete, P. Gorla, P. V. Guillaumon, S. Gupta, D. Hauff, M. Ješkovský, J. Jochum, M. Kaznacheeva, A. Kinast, H. Kluck, H. Kraus, S. Kuckuk, A. Langenkämper, M. Mancuso, L. Marini, B. Mauri, L. Meyer, V. Mokina, M. Olmi, T. Ortmann, C. Pagliarone, L. Pattavina, F. Petricca, W. Potzel, P. Povinec, F. Pröbst, F. Pucci, F. Reindl, J. Rothe, K. Schäffner, J. Schieck, D. Schmiedmayer, S. Schönert, C. Schwertner, M. Stahlberg, L. Stodolsky, C. Strandhagen, R. Strauss, I. Usherov, F. Wagner, V. Wagner, V. Zema   +59 more
doaj   +1 more source

End-to-end simulation of particle physics events with flow matching and generator oversampling

Machine Learning: Science and Technology
Abstract The simulation of high-energy physics collision events is a key element for data analysis at present and future particle accelerators. The comparison of simulation predictions to data allows looking for rare deviations that can be due to new phenomena not previously observed.
Francesco Vaselli, Filippo Cattafesta, Patrick Asenov, Andrea Rizzi   +3 more
openaire   +4 more sources