Results 51 to 60 of about 17,184 (253)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

NuGraph2 with context-aware inputs: physics-inspired improvements in semantic segmentation

Journal of High Energy Physics
Graph neural networks have recently shown strong promise for event reconstruction tasks in Liquid Argon Time Projection Chambers, yet their performance remains limited for underrepresented classes of particles, such as Michel electrons.
Vitor F. Grizzi, M. Voetberg, V. Hewes, Giuseppe Cerati, Hadi Meidani   +4 more
doaj   +1 more source

Baryon production from cluster hadronisation

European Physical Journal C: Particles and Fields, 2018
We present an extension to the colour reconnection model in the Monte Carlo event generator Herwig to account for the production of baryons and compare it to a series of observables for soft physics.
Stefan Gieseke, Patrick Kirchgaeßer, Simon Plätzer   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Improved modelling of SEP event onset within the WSA–Enlil–SEPMOD framework

Journal of Space Weather and Space Climate
Multi-spacecraft observations of solar energetic particle (SEP) events not only enable a deeper understanding and development of particle acceleration and transport theories but also provide important constraints for model validation efforts.
Palmerio Erika, Luhmann Janet G., Mays M. Leila, Caplan Ronald M., Lario David, Richardson Ian G., Whitman Kathryn, Lee Christina O., Sánchez-Cano Beatriz, Wijsen Nicolas, Li Yan, Cardoso Carlota, Pinto Marco, Heyner Daniel, Schmid Daniel, Auster Hans-Ulrich, Fischer David   +16 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Unveiling CP property of top-Higgs coupling with graph neural networks at the LHC

Physics Letters B, 2020
The top-Higgs coupling plays an important role in particle physics and cosmology. The precision measurements of this coupling can provide an insight to new physics beyond the Standard Model. In this paper, we propose to use Message Passing Neural Network
Jie Ren, Lei Wu, Jin Min Yang
doaj   +1 more source

Requirements on common solutions to the LSND and MiniBooNE excesses: a post-MicroBooNE study

Journal of High Energy Physics, 2022
The strong statistical significance of an observed electron-like event excess in the MiniBooNE (MB) experiment, along with an earlier similar excess seen in the Liquid Scintillator Neutrino Detector (LSND), when interpreted in conjunction with recent ...
Waleed Abdallah, Raj Gandhi, Samiran Roy
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source