Results 131 to 140 of about 3,483,849 (299)

Memory updating and the structure of event representations

Trends in Cognitive Sciences
People form memories of specific events and use those memories to make predictions about similar new experiences. Living in a dynamic environment presents a challenge: How does one represent valid prior events in memory while encoding new experiences when things change?
Christopher N. Wahlheim, Jeffrey M. Zacks   +1 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Electron-event representation data enable efficient cryoEM file storage with full preservation of spatial and temporal resolution. [PDF]

IUCrJ, 2020
Guo H, Franken E, Deng Y, Benlekbir S, Singla Lezcano G, Janssen B, Yu L, Ripstein ZA, Tan YZ, Rubinstein JL.   +9 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Implicit Neural Representation for Dense Event-Based Imaging Velocimetry

Mathematics
This paper presents an Implicit Neural Representation method for Event-Based Imaging Velocimetry (INR-VG) to reconstruct dense velocity fields from sparse event streams. The core idea is to learn a mapping (multilayer perceptron) from spatial coordinates
Jia Ai, Junjie Li, Zuobing Chen, Yong Lee   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

An EMF Framework for Event-B

, 2010
The Rodin platform for Event-B formal modelling is based on a bespoke model repository. While this approach has some advantages it also means that the platform does not benefit from the host of emerging technologies and supporting packages that are ...
Snook, Colin, Fritz, Fabian, Illisaov, Alexei   +2 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Infants' representations of michottean triggering events

Cognition
The classic Michottean 'launching' event is consistent with a real-world Newtonian elastic collision. Previous research has shown that adult humans distinguish launching events that obey some of the physical constraints on Newtonian elastic collisions from events that do not do so early in visual processing, and that infants do so early in development (
Kominsky, Jonathan F., Carey, Susan
openaire   +2 more sources